PMID: 696303Sep 1, 1978Paper

New knowledge in human milk immunoglobulin

Acta paediatrica Scandinavica
L A HansonC S Edén

Abstract

One of the anti-infection principles of maternal milk is the predominant milk immunoglobulin, secretory IgA. This immunoglobulin contains antibodies against many pathogens and potential pathogens, viruses as well as bacteria, including several members of Enterobacteriacae. The antigenic stimuli for these milk antibodies seem to take place in the Peyer's patches of the intestine. Lymphoid cells leaving the patches after antigenic exposure seem to home to the mammary glands via the lymph and blood circulation. As a result, the milk contains secretory IgA antibodies against, among other things, the intestinal bacteria of the mother. These milk antibodies might reflect the spectrum of bacteria and viruses in the community and may be important for the protection of the breast-fed baby. Via the same homing mechanism the maternal milk obtains antibodies against dietary antigens, including cow's milk proteins. Studies of infants on mixed feeding suggest that the secretory IgA antibodies against the bovine proteins diminish the antigenic exposure, indicating the possibility of an anti-allergic mechanism.

References

Dec 4, 1976·Lancet·D B McClelland, T T McDonald
Feb 12, 1977·Lancet·D J MatthewM W Turner
Oct 13, 1977·Nature·J HolmgrenH Lundbeck
Aug 1, 1977·The Journal of Infectious Diseases·J Holmgren, A M Svennerholm
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P Weisz-CarringtonM E Lamm
Mar 1, 1977·Acta paediatrica Scandinavica·V ReddyV Jagadeesan
Jan 1, 1977·International Archives of Allergy and Applied Immunology·L A HansonS P Fällström
Nov 1, 1977·The Journal of Experimental Medicine·M E RouxM E Lamm
Sep 1, 1975·Scandinavian Journal of Immunology·S AhlstedtR M Goldblum
Oct 30, 1975·Nature·R M GoldblumA Sohl-Akerlund
Jul 21, 1973·Lancet·B TaylorJ F Soothill
Mar 1, 1968·Pediatric Research·C W Smith, A S Goldman
Jan 1, 1974·International Archives of Allergy and Applied Immunology·B Haneberg
Dec 1, 1972·Archives of Disease in Childhood·L A Hanson, J Winberg
Jun 1, 1973·The Journal of Pediatrics·A S Goldman, C W Smith
Nov 1, 1974·Clinical Immunology and Immunopathology·E Diaz-Jouanen, R C Williams
Jul 1, 1971·The Journal of Experimental Medicine·S W Craig, J J Cebra

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Citations

Jan 1, 1995·Transplant International : Official Journal of the European Society for Organ Transplantation·H J MerhavD H Van Thiel
Nov 13, 2008·Infection and Immunity·Stefan SchildAndrew Camilli
Jul 1, 1985·Archives of Disease in Childhood·P Juto
Feb 1, 1991·Archives of Disease in Childhood·A PrenticeP G Lunn
Feb 1, 1980·Clinical and Experimental Hypertension : CHE·E ErikssonK Modigh
Apr 6, 2001·Journal of Clinical Laboratory Analysis·V TrégoatG Faure
Sep 1, 1981·The Journal of Pediatrics·S J GrossR G Faix
Apr 28, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A E SeppoK M Järvinen
Jan 1, 1987·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·H L VisP Hennart
Dec 1, 1979·Lancet·L CarrollA S McNeish
Dec 1, 1979·Lancet·M I Levene
Apr 1, 2002·Expert Review of Pharmacoeconomics & Outcomes Research·Wendy H Oddy
Nov 1, 1990·Acta paediatrica Scandinavica·N B MathurN Jain
Apr 5, 2000·The Veterinary Record·T W Pennycott
Jul 1, 1994·American Journal of Physical Anthropology·L M Hoshower
Jul 1, 1984·Indian Journal of Pediatrics·S Shashikala, J Prakash
Oct 1, 1983·Scandinavian Journal of Gastroenterology·O Bergstrand, G Hellers
Jan 1, 1985·Sozial- Und Präventivmedizin·U Ackermann-Liebrich, L Reber-Liebrich
Jan 1, 1983·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·G M Halpern
Jun 13, 2020·Frontiers in Microbiology·Ziyi WangShin-Yi Lee Marzano
Mar 7, 2021·Nutrients·Juan M RodríguezValerie Verhasselt
Jun 1, 1983·Current Problems in Pediatrics·K L CatesM Ballow

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