New lanostanes and naphthoquinones isolated from Antrodia salmonea and their antioxidative burst activity in human leukocytes

Planta medica
Chien-Chang ShenTun-Tschu Chang

Abstract

Four new compounds were isolated from the basidiomata of the fungus Antrodia salmonea, a newly identified species of Antrodia (Aphyllophorales) in Taiwan. These new compounds are named as lanosta-8,24-diene-3beta,15alpha,21-triol (1), 24-methylenelanost-8-ene-3beta,15alpha,21-triol (2), 2,3-dimethoxy-5-(2',5'-dimethoxy-3',4'-methylenedioxyphenyl)-7-methyl-[1,4]-naphthoquinone (3), and 2,3-dimethoxy-6-(2',5'-dimethoxy-3',4'-methylenedioxyphenyl)-7-methyl-[1,4]-naphthoquinone (4), respectively. Their structures were elucidated by spectroscopic methods. An in vitro cellular functional assay was performed to evaluate their anti-oxidative burst activity in human leukocytes. They showed inhibitory effects against phorbol 12-myristate-13-acetate (PMA), a direct protein kinase C activator, induced oxidative burst in neutrophils (PMN) and mononuclear cells (MNC) with 50 % inhibitory concentration (IC(50)) ranging from 3.5 to 25.8 microM. The potency order of these compounds in PMA-activated leukocytes was as 1 > 3 > 4 > 2. They were relatively less effective in formyl-Met-Leu-Phe (fMLP), a G-protein coupled receptor agonist, induced oxidative burst, except for compounds 3 and 4 in fMLP-activated PMN. These results indicated that three (...Continue Reading

Citations

Jan 7, 2014·Journal of Natural Products·Yun HuangMin Ye
Jul 30, 2008·Natural Product Reports·Joseph D Connolly, Robert A Hill
Dec 17, 2015·Journal of Asian Natural Products Research·Hong-Ru WuYing Zhu
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Feb 14, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Guan-Jhong HuangChieh-Hsi Wu
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Dec 31, 2019·Journal of Food and Drug Analysis·K J Senthil KumarSheng-Yang Wang

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