New life for an old antibiotic

ACS Applied Materials & Interfaces
Rahul Kumar MishraAharon Gedanken

Abstract

Restoring the antibacterial properties of existing antibiotics is of great concern. Herein, we present, for the first time, the formation and deposition of stable antibiotic nanoparticles (NPs) on graphene oxide (GO) sheets by a facile one-step sonochemical technique. Sonochemically synthesized graphene oxide/tetracycline (GO/TET) composite shows enhanced activity against both sensitive and resistant Staphylococcus aureus (S. aureus). The size and deposition of tetracycline (TET) nanoparticles on GO can be controlled by varying the sonication time. The synthesized NPs ranged from 21 to 180 nm. Moreover, ultrasonic irradiation does not cause any structural and chemical changes to the TET molecule as confirmed by Fourier transform infrared spectroscopy (FTIR). The virtue of π-π stacking between GO and TET additionally facilitate the coating of TET NPs upon GO. A time dependent release kinetics of TET NPs from the GO surface is also monitored providing important insights regarding the mechanism of antibacterial activity of GO/TET composites. Our results show that the GO/TET composite is bactericidal in nature, resulting in similar values of minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). This c...Continue Reading

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Citations

Feb 3, 2018·Applied Microbiology and Biotechnology·Arnau BassegodaTzanko Tzanov
Oct 1, 2020·Biomaterials Science·Shuting WangJian Ji
Nov 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rahul Kumar MishraEhud Banin
Feb 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·U Shimanovich, A Gedanken
Dec 4, 2020·Biomolecules·Mayra Eliana Valencia ZapataJosé Herminsul Mina Hernandez

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