PMID: 18406734Apr 1, 1996Paper

New light is shining on the melatonin rhythm enzyme: the first postcloning view

Trends in Endocrinology and Metabolism : TEM
D C KleinS L Coon

Abstract

One of the most interesting molecules in circadian biology is serotonin N-acetyltransferase (arylalkyfamine N-acetyltransferase, AANAT), the enzyme that controls the daily rhythm in pineal melatonin production and blood melatonin. The recent cloning of AANAT cDNA has led to the characterization of the human gene; the realization that AANAT represents a unique gene family; the discovery of circadian rhythms in AANAT mRNA; the determination of the basis of transsynaptic and cellular regulation of expression of the AANAT gene; a new understanding of the relationship of AANAT mRNA and activity; and the surprising finding of strong expression of the AANAT gene in the retina and significant levels in select brain regions, the pituitary gland, and testes. The cloning of AANAT cDNA has not only made it possible to answer longstanding questions in circadian biology, but has also raised stimulating new issues.

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Citations

Jan 15, 2014·Bioorganic & Medicinal Chemistry·Elodie LandagaraySaïd Yous
Sep 28, 1998·Brain Research. Developmental Brain Research·C RibelaygaV Simonneaux
Dec 5, 1998·Brain Research. Molecular Brain Research·P H RoseboomD C Klein
May 30, 1998·Neuroscience Letters·K Sakamoto, N Ishida
Aug 26, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P J NathanT R Norman
Jan 5, 1999·Bioorganic & Medicinal Chemistry Letters·S KloubertM Langlois
Jan 23, 2003·Bioorganic & Medicinal Chemistry·Cécile PégurierMonique Mathé-Allainmat
Feb 5, 2000·Bioorganic & Medicinal Chemistry·M Mathé-AllainmatM Langlois
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·M BernardM Zatz
Feb 21, 2014·Cellular and Molecular Life Sciences : CMLS·Darío Acuña-CastroviejoRussel J Reiter
Jun 23, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·José L P MuñozJesús M Míguez
Feb 20, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H WichtH W Korf
Mar 20, 1999·The Journal of Biological Chemistry·S L CoonD C Klein
Jul 11, 1996·Nature·J S Takahashi
May 21, 2009·The European Journal of Neuroscience·Prapimpun WongchitratValérie Simonneaux
May 13, 1999·Journal of Neurogenetics·J C Hall
Oct 7, 2000·Chronobiology International·G Tosini
Jan 29, 2004·Reproductive Medicine and Biology·Akihisa TakasakiHitoshi Morioka
Dec 1, 1996·Die Naturwissenschaften·H W KorfJ H Stehle
Feb 28, 1998·The Journal of Biological Chemistry·J De AngelisP A Cole
Oct 11, 2007·Journal of Medicinal Chemistry·Lawrence M SzewczukPhilip A Cole
May 5, 2021·Molecular Biology and Evolution·Daiqing YinGuang Yang

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