Jul 18, 2020

New light on cortical neuropeptides and synaptic network plasticity

Current Opinion in Neurobiology
Stephen J. SmithUygar Sümbül

Abstract

Neuropeptides, members of a large and evolutionarily ancient family of proteinaceous cell-cell signaling molecules, are widely recognized as extremely potent regulators of brain function and behavior. At the cellular level, neuropeptides are known to act mainly via modulation of ion channel and synapse function, but functional impacts emerging at the level of complex cortical synaptic networks have resisted mechanistic analysis. New findings from single-cell RNA-seq transcriptomics now illuminate intricate patterns of cortical neuropeptide signaling gene expression and new tools now offer powerful molecular access to cortical neuropeptide signaling. Here we highlight some of these new findings and tools, focusing especially on prospects for experimental and theoretical exploration of peptidergic and synaptic networks interactions underlying cortical function and plasticity.

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Mentioned in this Paper

Gene Expression Profiling
Finding
Neuropeptides
Brain
Cell Plasticity
Gene Expression
Theoretical Study
Intercellular Communication Process
Ion Channel
Cerebral Cortex

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