New light on the anti-colitic actions of therapeutic aminosalicylates: the role of heme oxygenase

Pharmacological Reports : PR
Brendan J R Whittle, Csaba Varga

Abstract

Although a variety of pharmaceutical preparations of aminosalicylate are commonly used in the clinic for the control of inflammatory bowel disease, the mechanisms underlying their therapeutic actions remain unclear. Recent in vivo and in vitro studies have demonstrated that 5-aminosalicylic acid (5-ASA), regarded as the active moiety in aminosalicylate preparations such as sulfasalazine, can induce the heat shock protein, heme oxygenase-1 (HO-1) and up-regulate HO enzyme activity in the colon. As HO-1 can produce endogenous anti-oxidant and anti-inflammatory moieties such as bilirubin and carbon monoxide (CO), these findings suggest a novel mechanism of action for aminosalicylates, acting as anti-colitic agents through the up-regulation of HO-1 enzyme expression and activity.

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Citations

Nov 30, 2011·Best Practice & Research. Clinical Gastroenterology·Christoph Campregher, Christoph Gasche
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Aug 23, 2011·Pharmacological Reports : PR·Byung-Min ChoiBok-Ryang Kim
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Jan 26, 2021·Oxidative Medicine and Cellular Longevity·Xiaoqing ChiSonghua Hu

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