New Lives Given by Cell Death: Macrophage Differentiation Following Their Encounter with Apoptotic Leukocytes during the Resolution of Inflammation.

Frontiers in Immunology
Amiram Ariel, C N Serhan

Abstract

Monocytes that migrate into tissues during inflammatory episodes and differentiate to macrophages were previously classified as classically (M1) or alternatively (M2) activated macrophages, based on their exposure to different fate-determining mediators. These macrophage subsets display distinct molecular markers and differential functions. At the same time, studies from recent years found that the encounter of apoptotic leukocytes with macrophages leads to the clearance of this cellular "debris" by the macrophages, while concomitantly reprogramming/immune-silencing the macrophages. While some of the features of M2 differentiation, such as arginase-1 (murine) and 15-lipoxygenases (human and murine) expression, were also displayed by macrophages following the engulfment of apoptotic cells, it was not clear whether apoptotic cells can be regarded as an M2-like differentiating signal. In this manuscript we review the recent information regarding the impact of apoptotic cells on macrophage phenotype changes in molecular terms. We will focus on recent evidence for the in vivo existence of distinct pro-resolving macrophages and the role of apoptotic cells, specialized lipid mediators, and glucocorticoids in their generation. Conseque...Continue Reading

Citations

Apr 16, 2013·Pharmacology & Therapeutics·Ana L AlessandriMauro M Teixeira
Mar 7, 2013·Cellular and Molecular Life Sciences : CMLS·Leo A B JoostenCharles A Dinarello
Sep 9, 2015·Journal of Autoimmunity·Daigo NakazawaAkihiro Ishizu
Jan 18, 2016·Biochemical Pharmacology·Ricardo CapeloAstrid S Kahnt
Oct 6, 2015·The Journal of Clinical Investigation·Arnaud MilletVéronique Witko-Sarsat
Jun 26, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E A JacobsenJ J Lee
Oct 17, 2014·Immunological Reviews·Partha Dutta, Matthias Nahrendorf
Jul 29, 2015·Seminars in Immunology·Madhur P Motwani, Derek W Gilroy
Apr 3, 2016·Seminars in Immunology·Nathalie ThieblemontVéronique Witko-Sarsat
Aug 20, 2014·Mediators of Inflammation·Denise Alves PerezVanessa Pinho
May 20, 2015·European Journal of Pharmacology·Dong-Soon Im
Jun 28, 2016·European Journal of Immunology·Amiram Ariel, Kodi S Ravichandran
May 4, 2016·European Journal of Immunology·Julianty AngsanaElliot L Chaikof
Jul 1, 2016·Antioxidants & Redox Signaling·Joslyn M AlbrightElizabeth J Kovacs
May 27, 2017·Blood·Pablo Pelegrín
Feb 9, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael R ElliottPatrick S Murphy
Dec 7, 2017·Frontiers in Immunology·Lívia C BarrosoMauro Martins Teixeira
Jan 15, 2013·Antioxidants & Redox Signaling·Bernhard BrüneAndreas Weigert
May 23, 2014·Antioxidants & Redox Signaling·Laura KuchlerAndreas von Knethen
Jul 16, 2014·Infection and Immunity·Tatiana de Oliveira FulcoRoberta Olmo Pinheiro
Jul 28, 2016·Infection and Immunity·Tsuguno YamaguchiToshihisa Kawai
Jan 1, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Julianty AngsanaElliot L Chaikof
Jul 25, 2018·European Journal of Clinical Investigation·Nathalie ThieblemontAmiram Ariel
Apr 3, 2019·European Journal of Immunology·Denise A PerezVanessa Pinho
Feb 11, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Neil R AggarwalFranco R D'Alessio
Mar 28, 2019·Anais Da Academia Brasileira De Ciências·Norma V Q CarneiroCamila A Figueiredo
Sep 19, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Adrian T BilleterHiram C Polk
Mar 19, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jesmond DalliCharles N Serhan
Sep 14, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nicolas H PopeGilbert R Upchurch
Feb 11, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Soumita DasPeter B Ernst
Jan 23, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Claire LastrucciCéline Cougoule
Jun 24, 2020·Stem Cells Translational Medicine·Erik BobergKatarina Le Blanc
Jul 31, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie GabilletVéronique Witko-Sarsat
Jul 16, 2020·American Journal of Physiology. Cell Physiology·János G Filep, Amiram Ariel

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