New losartan-hydrocaffeic acid hybrids as antihypertensive-antioxidant dual drugs: Ester, amide and amine linkers

European Journal of Medicinal Chemistry
Gonzalo GarcíaMaría L Díez-Marqués

Abstract

We report new examples of a series of losartan-hydrocaffeic hybrids that bear novel ester, amide and amine linkers. These compounds were made by linking hydrocaffeic acid to the side chain of losartan at the C-5 position of the imidazole ring through different strategies. Experiments performed in cultured cells demonstrate that these new hybrids retain the ability to block the angiotensin II effect and have increased antioxidant ability. Most of them reduced arterial pressure in rats better or as much as losartan.

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Citations

Jun 7, 2013·Medicinal Research Reviews·Ling ZhangCheng-He Zhou
Aug 22, 2020·Free Radical Biology & Medicine·Antonis D TsiailanisAndreas G Tzakos
Jan 19, 2019·ACS Medicinal Chemistry Letters·R Murray McKinnellUwe Klein

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