New macrocyclic diterpenoids from Euphorbia esula

Planta medica
L G LiuR X Tan

Abstract

The structures of two new macrocyclic jatrophane diterpenoid esters from the whole herb of Euphorbia esula, were established as 11,14-epoxy-3beta,5alpha,7beta,8alpha,9alpha,15beta-hexaacetoxy-12-oxo-13alphaH-jatropha-6(17)-ene (1) and 1alpha,3beta-diacetoxy-5alpha,7beta-dibenzoyloxy-9,14-dioxo-11beta,12alpha-epoxy-2alpha,8alpha,15beta-trihydroxy-13betaH-jatropha-6(17)-ene (2) by a combination of 1D- and 2D-NMR techniques as well as UV, IR and mass spectral data. Bioassay evaluation of all isolates against the human tumor cell lines (B16, KB, SMMC and BGC) indicated that ester 2 was cytotoxic to B16 with the IC50 value being 1.81 microg/ml. In addition, the irritant activity assay indicated that both diterpenoids were inactive (ID(24)50 > 100 microg/ear).

Citations

Nov 3, 2007·Phytochemistry·Zhi-Qiang LuDe-An Guo
Apr 13, 2013·Phytotherapy Research : PTR·Amani S AwaadAbd El Raheim M Donia
Jul 23, 2016·Journal of Natural Products·Bin ZhouJian-Min Yue
Apr 16, 2020·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Maryam FattahianIkhlas A Khan
Oct 11, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jie GuoXiao-Jiang Hao
Apr 3, 2020·Journal of Natural Products·Shengheng YuanQiong Gu

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