New macrolide, lincosaminide and streptogramin B antibiotics

Expert Opinion on Therapeutic Patents
Herbert A Kirst

Abstract

New antibiotics are needed to overcome microbial resistance and to improve on the therapeutic index and clinical effectiveness of existing agents. This review covers the journal and patent literature published from about the mid-2000s to 2010 to provide an overview of the large diversity of new chemical entities in the macrolide, lincosaminide and streptogramin B (MLS(B)) class. The review identifies areas of the greatest effort and recent results in pursuing structure-activity relationships among MLS(B) antibiotics and highlights preclinical and clinical candidates that have arisen from these diverse discovery programs. Research on the MLS(B) class appears promising for the eventual registration and commercialization of several new antibiotics that improve the clinical effectiveness of existing agents and combat antibiotic-resistant pathogens.

References

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Citations

Jan 31, 2015·International Journal of Environmental Research and Public Health·Jody L AndersenManuel F Varela
Mar 26, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Marios KrokidisGeorge P Dinos
Aug 27, 2014·Expert Opinion on Investigational Drugs·Nafsika H Georgopapadakou
Feb 19, 2013·Bioorganic & Medicinal Chemistry Letters·Thomas V MageeVeerabahu Shanmugasundaram
Dec 4, 2012·European Journal of Medicinal Chemistry·Jian-Hua LiangYing-Chun Xu
Mar 2, 2016·Advanced Drug Delivery Reviews·Christel A S BergströmChristopher J H Porter
Feb 7, 2012·Biochemistry·Mariya MorarGerard D Wright
Oct 7, 2016·Frontiers in Cellular and Infection Microbiology·Max R Schroeder, David S Stephens
Nov 6, 2013·Antimicrobial Agents and Chemotherapy·Marios G KrokidisGeorge P Dinos

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