New maresin conjugates in tissue regeneration pathway counters leukotriene D4 -stimulated vascular responses

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Nan ChiangCharles N Serhan

Abstract

Resolution of acute inflammation is governed, in part, by lipid mediator class switching from proinflammatory eicosanoids to specialized proresolving mediators, including a recently identified new pathway of mediators, termed maresin conjugates in tissue regeneration (MCTR), which includes MCTR1, MCTR2, and MCTR3. Here, we addressed whether each MCTR can impact the known vascular actions of cysteinyl leukotrienes. Leukotriene D4 (LTD4; 1.5 nmol/mouse) initiated vascular leakage in mouse cremaster vessels, which was reduced (>75%) by MCTR1 and MCTR2 (0.15 nmol each). With isolated Ciona intestinalis (sea squirt) primordial hearts, LTD4 (1-100 nM) induced negative inotropic action and lowered heartbeats 20-30%. Each MCTR (1-100 nM) prevented LTD4-reduced heart rates. With human cysteinyl leukotriene receptor-1 (CysLT1) expressed in CHO cells, each MCTR (10-100 nM) significantly reduced LTD4-initiated signaling. To assess the contribution of CysLT1 in the proresolving actions of MCTR, we carried out human macrophage (MΦ) phagocytosis. Each MCTR (0.1-10 nM) stimulated human MΦ phagocytosis of live Escherichia coli, whereas LTD4 did not stimulate phagocytosis. MCTR-activated phagocytosis was significantly blocked by a pharmacologic ...Continue Reading

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Citations

May 12, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jeevan Kumar Jadapalli, Ganesh V Halade
Sep 5, 2020·Essays in Biochemistry·Nan Chiang, Charles N Serhan
Nov 27, 2019·International Journal of Molecular Sciences·Sung-Min HwangChul-Kyu Park
Oct 29, 2019·The Journal of Clinical Investigation·Nan ChiangCharles N Serhan
May 18, 2021·Frontiers in Physiology·Alessandra MazzocchiCarlo Agostoni
Jun 29, 2021·Frontiers in Immunology·Christa DeckerGabrielle Fredman
Jul 13, 2021·Signal Transduction and Targeted Therapy·Huakan ZhaoYongsheng Li
Aug 18, 2021·Clinical Science·William S Powell

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