New Markers for Adult-Onset Still's Disease

Joint, Bone, Spine : Revue Du Rhumatisme
Stéphane Mitrovic, Bruno Fautrel

Abstract

Adult-onset Still's disease (AOSD) is a rare systemic auto-inflammatory disorder (SAID). Although the pathogenesis of the disease is complex and far from being fully understood, recent progresses in pathophysiological knowledge have paved the way to new diagnostic approaches. Indeed, AOSD diagnosis can be a real challenge, owing to its infrequency, and to the lack of specificity of the principal clinical features (high fever, arthralgia or arthritis, skin rash) and laboratory findings (elevated acute phase reactants, hyperleukocytosis≥10,000 cells/mm3 with neutrophils≥80%). None of these manifestations is disease-specific, so clinicians must first rule out neoplastic, infectious or inflammatory conditions. Besides these diagnostic difficulties, several other challenges remain. AOSD is very heterogeneous in terms of clinical presentation, evolution and severity. Thus, new biomarkers are required to assess: (i) disease activity; (ii) disease severity (through the identification of patients at risk of severe organ failure, and eventually of life-threatening complications, such as reactive haemophagocytic lymphohistiocytosis); (iii) disease evolution (which can be monophasic, relapsing, or progressive, with either systemic inflamma...Continue Reading

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Sep 16, 2018·Nature Reviews. Rheumatology·Eugen FeistBruno Fautrel
Oct 17, 2018·Expert Review of Clinical Immunology·Santos CastañedaMiguel A González-Gay
Mar 5, 2019·Expert Opinion on Biological Therapy·Santos CastañedaMiguel A González-Gay
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May 31, 2019·Clinical Reviews in Allergy & Immunology·Sheng LiJianjun Qiao
Apr 17, 2018·Expert Review of Clinical Immunology·Stéphane Mitrovic, Bruno Fautrel
May 21, 2020·Wiener klinische Wochenschrift·Mengying ZhangJun Zhou
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Mar 7, 2021·Journal of Clinical Medicine·Stylianos TomarasEugen Feist
Jul 3, 2021·Journal of Clinical Medicine·Stéphane Mitrovic, Bruno Fautrel

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Adult-Onset Still's Disease

Adult-onset Still's disease (AOSD) is a form of Still's disease, a rare systemic autoinflammatory disease characterized by the classic triad of persistent high spiking fevers, joint pain, and a distinctive salmon-colored bumpy rash. Discover the latest research on AOSD here.

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