New mechanisms for positive inotropic agents: focus on the discovery and development of imazodan

Cardiovascular Drugs and Therapy
R E WeishaarB A Klinkefus

Abstract

Intense efforts during the last decade to identify a useful positive inotropic agent to replace digitalis for the treatment of congestive heart failure have led to the discovery of several dozen potential substitutes, of which a number are currently undergoing clinical trials. In addition to producing a variety of new therapeutic entities, research in this area has also yielded valuable new information regarding the fundamental events that regulate calcium homeostasis and contractile function in the cardiac cell. For example, several of these new inotropic agents, including the calcium-channel stimulator BAY-k 8644, the sodium-channel stimulator DPI-201-186, and the sodium-calcium exchange inhibitor dichlorobenzamil, have provided considerable insight into the role of sodium and calcium in regulating contractility and the molecular events that mediate potential-dependent ion channels. Likewise, the discovery and development of agents like imazodan, amrinone, enoximone, and other selective type III phosphodiesterase inhibitors have provided new information regarding multiple molecular forms of cyclic nucleotide phosphodiesterase, compartmentation of cyclic AMP, and the importance of soluble vs. membrane-bound phosphodiesterases.

References

Jan 1, 1979·Journal of Cardiovascular Pharmacology·R K SainiB C Pressman
Feb 1, 1979·Circulation Research·G I Drummond, D L Severson
Mar 1, 1979·The American Journal of Physiology·L J Mullins
Feb 1, 1977·Circulation Research·A Fabiato, F Fabiato
Aug 1, 1979·Circulation·J J KronenfeldR O Russell
Nov 1, 1985·Journal of Cardiovascular Pharmacology·R P Hof, A Hof
Feb 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G RomeyM Lazdunski
Jan 1, 1988·Annual Review of Neuroscience·R L Barchi
Nov 1, 1989·Canadian Journal of Physiology and Pharmacology·S J HaleenR E Weishaar
Oct 1, 1987·Journal of Molecular and Cellular Cardiology·R E WeishaarH R Kaplan
Mar 1, 1985·Journal of Molecular and Cellular Cardiology·E Carafoli
May 1, 1987·British Journal of Pharmacology·A J KaumannD A Russell
Dec 17, 1985·European Journal of Pharmacology·R E WeishaarD B Evans
Feb 11, 1988·The New England Journal of Medicine·T W Smith
Dec 1, 1987·The American Journal of Cardiology·J B KostisL A Casazza
Feb 1, 1986·The American Journal of Cardiology·S M JafriS Goldstein
Nov 15, 1973·Journal of Molecular Biology·S E HitchcockA G Szent-Györgyi
Jul 1, 1972·Circulation·D S Lukas
Jan 1, 1982·Pharmacology & Therapeutics·D B EvansH R Kaplan
Nov 1, 1983·Journal of the American College of Cardiology·M Packer
May 16, 1984·Biochemical and Biophysical Research Communications·C MontielA G García
Aug 1, 1984·The American Journal of Cardiology·B F UretskyR A Okerholm
Jan 1, 1982·Reviews of Physiology, Biochemistry and Pharmacology·P Honerjäger
Aug 1, 1984·Journal of the American College of Cardiology·H Scholz
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P K SieglG J Kaczorowski

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