New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

Oncogene
K L PierceRobert J Lefkowitz

Abstract

Activation of classical second messenger cascades cannot fully explain the recently appreciated roles of heptahelical, or G-protein coupled receptors (GPCRs), in stimulation of mitogen activated protein kinase (MAPK) cascades. Rather, several distinct signaling mechanisms appear to contribute to GPCR-mediated MAPK activation. These include transactivation of the Epidermal Growth Factor Receptor (EGFR) via the autocrine/paracrine release of EGF-like ligands at the cell surface and scaffolding of MAPK cascades. A significant advance in the understanding of how GPCRs activate MAPK cascades is the discovery that beta-arrestin, a protein well known for its roles in both receptor desensitization and internalization, serves as a scaffolding protein for at least two GPCR stimulated MAPK cascades, the extracellular signal regulated kinase (ERK) cascade and the c-jun N-terminal kinase 3 (JNK3) cascade. Together, these novel mechanisms of GPCR-mediated MAPK regulation may permit GPCRs in specific situations to control the temporal and spatial activity of MAPKs and thereby determine the consequences of GPCR stimulation with respect to transcriptional activation, cell proliferation and apoptosis.

References

Apr 1, 1994·Journal of Cellular Biochemistry·G L JohnsonS Winitz
Jan 31, 1998·The EMBO Journal·H DaubA Ullrich
Jan 13, 1998·Biochimica Et Biophysica Acta·G Raab, M Klagsbrun
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·A HerrlichT Gudermann
Feb 13, 1999·The Journal of Biological Chemistry·G J Della RoccaJ R Raymond
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·S A LaporteL S Barak
Apr 10, 1999·The Journal of Biological Chemistry·J L DeGraffM J Orsini
Apr 23, 1999·The Journal of Biological Chemistry·O VöglerC J van Koppen
Aug 24, 1999·The Journal of Biological Chemistry·J L Whistler, M von Zastrow
Sep 22, 1999·Molecular and Cellular Biology·J YasudaR J Davis
Dec 10, 1999·The Journal of Biological Chemistry·O KranenburgW H Moolenaar
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·K L PierceR J Lefkowitz

❮ Previous
Next ❯

Citations

Dec 6, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Christopher S KnauerLawrence W Fitzgerald
Sep 18, 2013·Experimental Brain Research·Evelien GellynckKathleen Van Craenenbroeck
Jul 14, 2005·Cancer Chemotherapy and Pharmacology·Keisuke YamaguchiMadan M Kwatra
Jul 19, 2013·Journal of Molecular Neuroscience : MN·Maosheng Xia, Yue Zhu
Jul 17, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Arthur D Conigrave, Donald T Ward
Nov 25, 2004·International Journal of Cardiology·Christodoulos FlordellisHervé Paris
Jun 14, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hildegard M Schuller, Maria Cekanova
May 3, 2003·Pharmacology & Therapeutics·Chris J van Koppen, Björn Kaiser
Jul 2, 2003·Cellular Signalling·Gunnar Schulte, Bertil B Fredholm
Apr 30, 2002·Trends in Cell Biology·Boris N Kholodenko
Apr 3, 2003·Trends in Endocrinology and Metabolism : TEM·Walter G Thomas, Hongwei Qian
Jun 19, 2002·Biochimica Et Biophysica Acta·Yehia Daaka
May 16, 2003·Vascular Pharmacology·Natalia V BogatchevaAlexander D Verin
Jul 1, 2008·Nature Methods·Paulina CarribaRafael Franco
Jan 5, 2011·Nature Reviews. Drug Discovery·Rosamaria Lappano, Marcello Maggiolini
Apr 20, 2004·Assay and Drug Development Technologies·Deirdre K Luttrell, Louis M Luttrell
Aug 12, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Amrita KamatMichael S Katz
Dec 16, 2010·Human Reproduction·Yasushi KawanoHisashi Narahara
Jan 13, 2006·Clinical and Experimental Pharmacology & Physiology·Nanda Tilakaratne, Patrick M Sexton
Nov 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Mariana M BelchevaCarmine J Coscia
Nov 4, 2005·Science's STKE : Signal Transduction Knowledge Environment·Sudha K Shenoy, Robert J Lefkowitz
Jun 12, 2002·Canadian Journal of Physiology and Pharmacology·Louis M Luttrell
Apr 25, 2003·Canadian Journal of Physiology and Pharmacology·Fernand GobeilSylvain Chemtob
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Christopher M TanLee E Limbird
Dec 7, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Wayne C H WangStephen B Liggett
Apr 12, 2002·Neuro-Signals·Mariana M Belcheva, Carmine J Coscia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis