New Medications Are Needed for Children With Juvenile Idiopathic Arthritis.

Arthritis & Rheumatology
Hermine I BrunnerPRCSG Advisory Council and the CARRA Registry Investigators

Abstract

To document the need for additional Food and Drug Administration (FDA)-approved medications for the treatment of juvenile idiopathic arthritis (JIA). The electronic medical records of JIA patients treated at Cincinnati Children's Hospital Medical Center (CCHMC) and data from JIA patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry were included in this study. Unmet medication need was defined in 2 ways: (a) the presence of chronically uncontrolled JIA, defined as a physician global assessment of JIA activity ≥3 (on a 0-10 scale, where 0 = inactive) OR ≥3 joints with active arthritis OR a patient global assessment of well-being ≥3 (on a 0-10 scale, where 0 = very well), despite sequential use of ≥2 biologic disease-modifying antirheumatic drugs (bDMARDs); and (b) the use of ≥1 bDMARD not approved for any JIA category. At CCHMC, 829 of 1,599 JIA patients (52%) were treated with ≥1 bDMARD, and 304 (19%) had been exposed to ≥1 unapproved bDMARD. In the CARRA Registry, 4,766 of 7,379 children (65%) had received ≥1 bDMARD, and 1,122 (15%) had been prescribed ≥1 unapproved bDMARD. Of those children treated with ≥2 bDMARDs for whom complete data were available, 52% (255 of 487) at CCHMC and 4...Continue Reading

References

Sep 1, 2007·Arthritis and Rheumatism·Nicolino RupertoUNKNOWN Pediatric Rheumatology Collaborative Study Group

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Citations

Jun 15, 2021·Frontiers in Medicine·Judith A Smith, Ruben Burgos-Vargas
Jul 14, 2021·Current Rheumatology Reports·Hemalatha SrinivasaluChristopher Redmond

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