New metabolites from the sponge Spongia agaricina

Journal of Natural Products
A RuedaJ Salvá

Abstract

The sponge Spongia agaricina from Tarifa, Cadiz, Spain, contains two new 9,11-secosterols, [3-0-deacetylluffasterol B (1) and 3-0-deacetyl-22,23-dihydro-24,28-dehydroluffasterol B (2)] and two new sesterterpenoids [12,16-di-epi-12-0-deacetyl-16-0-acetylfuroscalarol (3) and 16-epi-scalarolbutenolide (4)], in addition to the known compounds 5-15. The structures of all compounds were elucidated by interpretation of' spectroscopic data. The metabolites 1-3 showed significant cytotoxicity against four tumor cell lines (C50 1 microgram/mL).

References

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Citations

Nov 23, 2007·Natural Product Reports·Yonghong LiuSi Zhang
Jun 24, 2011·PloS One·Charlotte NoyerMikel A Becerro
Dec 24, 2013·Steroids·Malika Ibrahim-Ouali, Khalil Hamze
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Mar 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yeon-Ju LeeJihoon Lee
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Nov 1, 2008·Journal of Natural Products·Jueun SongJongheon Shin
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