New Method for the Approximation of Corrected Calcium Concentrations in Chronic Kidney Disease Patients

Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Yoshio KakuKaoru Tabei

Abstract

The following conventional calcium correction formula (Payne) is broadly applied for serum calcium estimation: corrected total calcium (TCa) (mg/dL) = TCa (mg/dL) + (4 - albumin (g/dL)); however, it is inapplicable to chronic kidney disease (CKD) patients. A total of 2503 venous samples were collected from 942 all-stage CKD patients, and levels of TCa (mg/dL), ionized calcium ([iCa(2+) ] mmol/L), phosphate (mg/dL), albumin (g/dL), and pH, and other clinical parameters were measured. We assumed corrected TCa (the gold standard) to be equal to eight times the iCa(2+) value (measured corrected TCa). Then, we performed stepwise multiple linear regression analysis by using the clinical parameters and derived a simple formula for corrected TCa approximation. The following formula was devised from multiple linear regression analysis: Approximated  corrected TCa (mg/dL) = TCa + 0.25 × (4 - albumin) + 4 × (7.4 - p H) + 0.1 × (6 - phosphate) + 0.3. Receiver operating characteristic curves analysis illustrated that area under the curve of approximated corrected TCa for detection of measured corrected TCa ≥ 8.4 mg/dL and ≤ 10.4 mg/dL were 0.994 and 0.919, respectively. The intraclass correlation coefficient demonstrated superior agreement ...Continue Reading

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Citations

Sep 23, 2016·Expert Review of Medical Devices·Manoj K SharmaJeroen P Kooman
Nov 2, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yoshitsugu ObiKamyar Kalantar-Zadeh
Jan 18, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yoshitsugu ObiElani Streja
Sep 2, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Jean-David PekarPatrice Maboudou
May 24, 2020·The Journal of Applied Laboratory Medicine·Ernie YapPhilip Goldwasser

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