New method of radiotherapy for anal cancer with three-dimensional tumor reconstruction based on endoanal ultrasound and ultrasound-guided afterloading therapy

Diseases of the Colon and Rectum
M LöhnertP Dohrmann

Abstract

Standard treatment of anal cancer is a protocol of combined chemotherapy and percutaneous radiotherapy. We developed a new endosonography-based radiation target simulation method, because endoanal sonography gives the best opportunity to stage the tumor accurately. Based on this method, an afterloading needle application procedure could be performed to optimize the radiation target geometry and to control the application of afterloading needles. In a prospective study, this new method was evaluated, with special regard for complications and tumor recurrence. Anal cancer was restaged endosonographically six weeks after external beam radiation with 45 Gy. A computer-generated three-dimensional reconstruction of the tumor and radiation target simulation was performed based on endoanal sonographic imaging. By using a new type of applicator, which is permeable to ultrasound waves, the transperineal implantation procedure of afterloading needles could be controlled. Application needles were inserted into the target area according to the endoanal sonography-based dosimetry planing. The dose of the (high-dose rate) brachytherapy boost was started with two 6-Gy fractions, each within eight days. The fraction dose was reduced to 4 Gy to ...Continue Reading

References

Sep 1, 1992·International Journal of Colorectal Disease·G LindmarkB Glimelius
Jan 1, 1991·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·C W SomawardhanaR M Lambrecht
Aug 1, 1991·International Journal of Colorectal Disease·S GoldmanB Glimelius
Dec 1, 1991·AJR. American Journal of Roentgenology·M B NielsenJ Christiansen
Jan 1, 1989·Gastrointestinal Radiology·P J Law, C I Bartram
Jan 1, 1985·Diseases of the Colon and Rectum·U Hildebrandt, G Feifel
Dec 9, 1994·Deutsche medizinische Wochenschrift·M LöhnertJ M Doniec
Apr 1, 1993·The British Journal of Surgery·A H SultanC I Bartram
Jun 1, 1996·Diseases of the Colon and Rectum·M HünerbeinP M Schlag

❮ Previous
Next ❯

Citations

Apr 12, 2008·Magyar onkologia·Félix SzentpéteryFerenc Jakab
Aug 23, 2005·Expert Review of Anticancer Therapy·Robert F Wong, Manoop S Bhutani
May 30, 2006·Hematology/oncology Clinics of North America·Arthur Y HungLisa A Kachnic
Jul 21, 2004·The Surgical Clinics of North America·David M Schaffzin, W Douglas Wong
Nov 6, 2004·The Medical Clinics of North America·Radha TamerisaManoop S Bhutani
Nov 17, 2005·Psycho-oncology·Daniel A MontiGeorge C Brainard
Aug 24, 2000·International Journal of Cancer. Journal International Du Cancer·P K SelboK Berg
Feb 3, 2004·Lasers in Surgery and Medicine·Jui-Chang TsaiTsuimin Tsai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Matthias Stelzner
The Surgical Clinics of North America
T J Saclarides
Journal of Clinical Ultrasound : JCU
A S Lübbe, C Bergemann
© 2022 Meta ULC. All rights reserved