New methodology for evaluating osteoclastic activity induced by orthodontic load

Journal of Applied Oral Science : Revista FOB
Adriele Silveira AraújoAna Maria Bolognese

Abstract

Orthodontic tooth movement (OTM) is a dynamic process of bone modeling involving osteoclast-driven resorption on the compression side. Consequently, to estimate the influence of various situations on tooth movement, experimental studies need to analyze this cell. Objectives The aim of this study was to test and validate a new method for evaluating osteoclastic activity stimulated by mechanical loading based on the fractal analysis of the periodontal ligament (PDL)-bone interface. Material and Methods The mandibular right first molars of 14 rabbits were tipped mesially by a coil spring exerting a constant force of 85 cN. To evaluate the actual influence of osteoclasts on fractal dimension of bone surface, alendronate (3 mg/Kg) was injected weekly in seven of those rabbits. After 21 days, the animals were killed and their jaws were processed for histological evaluation. Osteoclast counts and fractal analysis (by the box counting method) of the PDL-bone interface were performed in histological sections of the right and left sides of the mandible. Results An increase in the number of osteoclasts and in fractal dimension after OTM only happened when alendronate was not administered. Strong correlation was found between the number of...Continue Reading

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Citations

Jan 28, 2016·Journal of Applied Oral Science : Revista FOB·Y I JianruZhihe Zhao
Jun 28, 2017·Orthodontics & Craniofacial Research·J S FranzoniM Santamaria
Dec 24, 2017·Photochemistry and Photobiology·Viviane JettarAguinaldo S Garcez
Jun 24, 2017·Journal of Oral Science·Hossam AsaadOmar Kujan
Mar 21, 2018·International Journal of Oral Science·Yoshiko ArijiEiichiro Ariji
Jun 24, 2017·Journal of Oral Science·Fatma Y KırzıoğluHikmet Orhan
Dec 11, 2020·Clinical and Experimental Dental Research·Hussein Abid Ali Muhsin Alnajar, Dheaa H Al Groosh
Jul 9, 2020·Orthodontics & Craniofacial Research·Luiza Lassi de Araújo LopesPhillipe Nogueira Barbosa Alencar

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Methods Mentioned

BETA
sedation
light microscopy

Software Mentioned

Analyze Tools
ImageJ
Image J
Photoshop
Fractal Box Counter

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