Jul 14, 2016

New methods to detect autophagic flux

Yao xue xue bao = Acta pharmaceutica Sinica
Xiao-xi Lü, Zhuo-wei Hu

Abstract

Autophagy is a crucial biological process of eukaryotes, which is involved in cell growth, survival and energy metabolism, while the premise of the autophagy function is activated autophagic flux. It has been confirmed that impaired autophagic flux promotes pathogenesis of many chronic inflammatory diseases, especially cancer, neurodegenerative disease and tissue fibrosis, therefore the analysis of autophagic flux state is important for revealing autophagy function and the mechanism of autophagy related diseases. Given that autophagy is a dynamic process with multiple steps, it is very hard to observe the real state of autophagic flux. Summarized here is the novel concept and current approach to detect autophagic flux. This knowledge is crucial for the researching of the biological function of autophagy, and may provide some strategies for developing autophagy-related drug.

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Mentioned in this Paper

Pathogenic Aspects
Pathogenesis
Chronic Inflammatory Disorder
Vacuolar Myopathy
Energy Metabolism
Cirrhosis
Degenerative Diseases, Spinal Cord
Nerve Degeneration
Cell Growth
Inflammation

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