PMID: 9186226Jun 1, 1997Paper

New model for chronic osteomyelitis with Staphylococcus aureus in sheep

Clinical Orthopaedics and Related Research
S KaarsemakerA E vd Bogaard

Abstract

The purpose of this study was to develop a large animal model for chronic osteomyelitis, suitable for toxicologic research and therapeutic intervention studies. Osteomyelitis was induced in 52 healthy adult Texel sheep by injecting a sclerosing agent and a hemolytic strain of Staphylococcus aureus into the proximal tibial marrow cavity. Evaluation was done by clinical, radiologic, bacteriologic, and histologic parameters for 3 months. Clinical signs of infection consisted of localized soft tissue swelling, pain during the acute phase, and limping in all sheep. Radiologic features were moderate to extensive periosteal reaction, cortical lysis, mild to extensive new bone formation, and frequent development of sequestra limited to the proximal part of the tibia. Cultures were positive for the same strain of Staphylococcus aureus in all but one sheep. Histology showed chronic active inflammation, osteolysis, new woven bone formation, debris, clusters of bacteria, and surrounding granulation tissue. It was necessary to administer a single prophylactic dose of antibiotics 1 hour after surgery to prevent fatal sepsis. It was concluded that sheep are a suitable model for chronic osteomyelitis.

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Citations

Sep 30, 2004·The Journal of Oral Implantology·H W Anselm WiskottUrs C Belser
Aug 7, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Dan LiEdward M Schwarz
Jan 6, 2009·Biogerontology·Felícito García-AlvarezRicardo Lozano
Jul 5, 2005·Clinical Orthopaedics and Related Research·Christopher J SalgadoBruce Veit
Apr 15, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Leah H CobbLauren B Priddy
May 18, 2006·The International Journal of Artificial Organs·Y H AnC R Arciola
Dec 1, 2014·Journal of Experimental Orthopaedics·Brian D MarianiRocky S Tuan
Jun 6, 2006·Acta Orthopaedica·Thomas KalteisKlaus Lerch
Oct 20, 2006·Plastic and Reconstructive Surgery·Christopher J SalgadoHung-Chi Chen
Apr 12, 2012·Journal of Biomedical Materials Research. Part a·Dustin L WilliamsRoy D Bloebaum
Aug 7, 2019·Disease Models & Mechanisms·Monika J TomeckaTom J Carney
Mar 20, 2021·Animal Models and Experimental Medicine·Kylie M RouxLauren B Priddy
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aage Kristian Olsen AlstrupPia Afzelius

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