New monoclonal antibodies recognizing epidermal differentiation-associated keratins in formalin-fixed, paraffin-embedded tissue. Keratin 10 expression in carcinoma of the vulva.

The Journal of Pathology
D IvanyiA P Heintz

Abstract

Two monoclonal antibodies (MAb) specific for differentiation-related epidermal keratins have been developed. They represent specific molecular probes for different stages of epidermal differentiation. Antibody DE-K10 is chain-specific for cytokeratin polypeptide no. 10 (56.5 kD) expressed in all suprabasal layers of the epidermis. Antibody DE-SCK is specific for modified stratum corneum keratins and thus represents a marker for the terminal step of epidermal differentiation. Since the epitopes identified by both antibodies are preserved in formalin-fixed, paraffin-embedded tissue sections, these antibodies can be used for retrospective studies of differentiation in various pathological processes. We have used antibody DE-K10 to study the cytokeratin 10 expression in 26 stage II or III vulvar squamous cell carcinomas. Preliminary data suggest an increased risk of recurrence in cytokeratin 10 negative tumours.

References

Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T T SunH Green
Jan 1, 1985·Annals of the New York Academy of Sciences·R A QuinlanW W Franke
Jan 1, 1985·Annals of the New York Academy of Sciences·T T SunR Eichner
May 1, 1987·Experimental Cell Research·F RamaekersP Vooijs
Mar 1, 1988·American Journal of Clinical Pathology·N W ChinK W Lanks
Nov 1, 1982·The Journal of Cell Biology·J Woodcock-MitchellT T Sun
Nov 1, 1982·Journal of Clinical Pathology·K C GatterD Y Mason
Jan 1, 1983·Differentiation; Research in Biological Diversity·R MollW W Franke
Jul 1, 1983·The Journal of Investigative Dermatology·T T SunJ Woodcock-Mitchell

❮ Previous
Next ❯

Citations

May 8, 2008·Histochemistry and Cell Biology·Roland MollLutz Langbein
Jan 30, 2004·Oral Oncology·Ojaswini S UpasaniAvinash N Bhisey
Dec 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A CoquetteY Poumay
Jun 17, 1998·Genes & Development·E Robanus-MaandagH te Riele
Dec 1, 1994·The British Journal of Dermatology·A Ishida-YamamotoK A Holbrook
Sep 2, 2014·The Journal of Investigative Dermatology·Christine NeumannPaul L Bigliardi
Sep 6, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Christian StollJoachim Alfer
Aug 22, 2006·Journal of Cutaneous Pathology·Figen AslanNükhet Tüzüner
May 9, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·H HamakawaH Tanioka
Nov 1, 1996·Nature Medicine·K A ChoateP A Khavari
Sep 1, 1993·Health Care for Women International·B KeddyJ Melanson
Jul 4, 2020·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jiyoung Kim, René Villadsen
Aug 18, 2020·The Journal of Investigative Dermatology·Veronika RamovsArnoud Sonnenberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.