New mouse models for chronic Cryptosporidium infection in immunodeficient hosts.

Infection and Immunity
B L UngarF D Finkelman

Abstract

Cryptosporidium sp. causes fulminant diarrhea and chronic infection in immunocompromised, particularly human immunodeficiency virus-infected, persons. The lack of in vitro cultivation and a suitable animal model has limited development of effective treatment. We describe two new mouse models of chronic symptomatic cryptosporidiosis in adult athymic mice and in T-cell subset-depleted mice. A progressive infection, fatal within 4 months, occurred in most adult athymic mice; a few developed stable infections. Symptoms included dehydration, weight loss, intermittent diarrhea, and jaundice. Pathologic abnormalities and organisms localized in the intestine in stable infections but involved the hepatobiliary tree and pancreas in others. Lymphoid cells from histocompatible, Cryptosporidium sp.-immune mice cured infected nude mice. Identical infections occurred in neonatally infected BALB/c mice treated with anti-CD4 monoclonal antibodies alone or also with anti-CD8 monoclonal antibodies; the mice were cured when the monoclonal antibody treatments were stopped. These models will be useful in definition of the immune defects that permit chronic cryptosporidiosis to develop and in assessment of treatment modalities.

References

Dec 25, 1986·The New England Journal of Medicine·L Jokipii, A M Jokipii
Jul 1, 1988·Infection and Immunity·M E RoseD Wakelin
Jun 1, 1987·The Journal of Experimental Medicine·M F HeyworthT H Ermak
Aug 1, 1986·Annals of Internal Medicine·S J MargulisI M Jacobson
Nov 1, 1988·The Journal of Infectious Diseases·D Baxby, N Blundell
Jan 1, 1988·Critical Reviews in Microbiology·F G Crawford, S H Vermund
Feb 21, 1987·British Medical Journal·S P HawkinsC Teasdale
Dec 1, 1988·The Journal of Infectious Diseases·J E RehgD B Woodmansee
Jul 1, 1988·Revista Do Instituto De Medicina Tropical De São Paulo·R M DiasP P Chieffi
May 1, 1988·Gut·G M ConnollyB G Gazzard
May 1, 1988·Journal of Clinical Microbiology·P BrasseurJ J Ballet
Dec 1, 1986·Microbiological Reviews·R Fayer, B L Ungar
Nov 1, 1986·Reviews of Infectious Diseases·R Soave, D Armstrong
Apr 1, 1987·Annals of Internal Medicine·D J SchneidermanF C Laing
Nov 1, 1987·Infection and Immunity·J E RehgD B Woodmansee
Oct 1, 1986·Infection and Immunity·E M LieblerD B Woodmansee
Jan 1, 1987·The Journal of Infectious Diseases·T R Navin, A M Hardy
Mar 1, 1987·The American Journal of Tropical Medicine and Hygiene·J K Stehr-GreenD D Juranek
Feb 1, 1986·The Journal of protozoology·W L Current, N C Reese
Dec 1, 1983·The Journal of Infectious Diseases·W L Current, P L Long
Mar 1, 1984·Infection and Immunity·J HeineD B Woodmansee
May 11, 1984·Science·W L Current, T B Haynes
Nov 1, 1982·Infection and Immunity·D SherwoodS Tzipori

❮ Previous
Next ❯

Citations

Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J StephensA Hayward
Oct 31, 2007·Infection and Immunity·Birte PantenburgA Clinton White
Jun 13, 2019·Parasitology Research·Shahira A AhmedPanagiotis Karanis
Jan 1, 1990·Annals of the New York Academy of Sciences·R Soave
Dec 21, 2000·Parasite Immunology·V McDonald
Jul 30, 2003·Animal Health Research Reviews·James A Harp
Oct 28, 2011·Expert Review of Anti-infective Therapy·Vincent McDonald
Dec 1, 1990·Gut·M E CaselliV Alvisi
Nov 24, 2012·Parasite Immunology·V McDonaldF Petry
Aug 31, 2014·Clinical Reviews in Allergy & Immunology·Marion J Pollheimer, Peter Fickert
Jun 30, 2011·The Journal of Parasitology·Lourrany B CostaCirle Alcantara Warren
Jul 1, 1994·Journal of Medical Primatology·F J KaupG Hunsmann
Jun 14, 2018·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Paulo Eduardo Ferlini TeixeiraRosângela Rodrigues-Silva
Apr 16, 2013·Gastroenterology·Gideon M HirschfieldAndrew L Mason
Feb 1, 1995·International Journal for Parasitology·P J O'Donoghue
Sep 2, 1998·International Journal for Parasitology·M S Abrahamsen
Nov 27, 1999·International Journal for Parasitology·D C de GraafA Bonnin
Oct 22, 2013·Molecular Aspects of Medicine·Marion J PollheimerBruno Stieger
Feb 1, 1991·Infection and Immunity·J A Harp, H W Moon
Oct 23, 1997·Clinical Microbiology Reviews·L RomaniF Bistoni
Oct 1, 1991·Infection and Immunity·J M BjornebyL E Perryman
Jan 1, 1994·Infection and Immunity·J D ThulinH B Gelberg
Apr 1, 1993·Antimicrobial Agents and Chemotherapy·P BrasseurJ J Ballet

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

© 2021 Meta ULC. All rights reserved