New myrsinol diterpenes from Euphorbia prolifera and their inhibitory activities on LPS-induced NO production

Bioorganic & Medicinal Chemistry Letters
Jing XuYasushi Ohizumi

Abstract

A phytochemical investigation of the roots of Euphorbia prolifera led to the isolation of ten new myrsinol diterpenes, named euphorbialoids A-J (1-10), and two known analogues (11 and 12). Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) spectroscopic data analyzes, and the structures of 1 and 9 were confirmed by X-ray crystallography. The inhibitory activities on LPS-induced NO production of these diterpenes were evaluated and all the compounds showed inhibitory effects.

Citations

Aug 1, 2012·Journal of Natural Medicines·Jing XuYasushi Ohizumi
Jul 25, 2012·Journal of Agricultural and Food Chemistry·Jing XuLingzhi Fang
Dec 26, 2015·Journal of Natural Products·Jin Woo LeeBang Yeon Hwang
Jun 13, 2015·Journal of Agricultural and Food Chemistry·Jing XuYuanqiang Guo
Jan 22, 2015·Natural Product Research·Li WangYong Zhao
Oct 15, 2014·Saudi Journal of Biological Sciences·Taewoo JooJin-Woo Jhoo
Jun 17, 2016·Phytotherapy Research : PTR·Md Torequl IslamAna Amélia de Carvalho Melo-Cavalcante
Aug 11, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jing XuYuanqiang Guo
Aug 15, 2013·Natural Product Reports·James R Hanson
Jul 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdelsamed I ElshamyMohamed-Elamir F Hegazy
Feb 21, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan-Bo QuJing Zhang

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