PMID: 9164250May 1, 1997Paper

New nonpurified diet (NTP-2000) for rodents in the National Toxicology Program's toxicology and carcinogenesis studies

The Journal of Nutrition
G Rao

Abstract

The NIH-07 open-formula nonpurified diet was the selected diet for rodents in the National Toxicology Program's toxicology and carcinogenesis studies from 1980 to 1994. Protein and mineral concentrations of the NIH-07 diet may have increased some diet- and age-associated lesions such as nephropathy. A number of experimental nonpurified diets with lower protein and higher fat and fiber (approximately 15% protein, 7-8.5% fat, and 9-14% crude fiber) than the NIH-07 diet were formulated and evaluated in Fischer 344 (F344) rats. Decreasing protein content of the diet decreased protein consumption by approximately 30% and decreased severity of nephropathy without affecting growth. Increased fat intake seemed to have decreased the incidence or severity of leukemia, a lethal neoplasm of F344 rats. Increasing fiber content without decreasing the caloric density lowered body weight gain and slowed growth of mammary tumors. Higher fat and/or fiber intake decreased the incidences of adrenal pheochromocytomas and medullary hyperplasia in male rats. Nonpurified diets with lower protein and higher fat and fiber concentrations than the NIH-07 diet decreased or delayed diet- and age-associated lesions and increased survivals in 2-y studies. On ...Continue Reading

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Citations

Oct 10, 2002·Toxicologic Pathology·Vladimir S TurusovGary A Boorman
Feb 25, 2009·Laboratory Animals·I H E KasanenT O Nevalainen
Jul 10, 2003·International Journal of Occupational and Environmental Health·James Huff
Jan 7, 2003·Toxicologic Pathology·Ghanta N Rao
Jan 11, 2008·Journal of Animal Physiology and Animal Nutrition·B PastuszewskaA Morawski
Jul 27, 2007·Physiological Genomics·J Todd AumanRichard S Paules
Feb 28, 2004·The Journal of Nutrition·Kevin A Cockell, Bartholomeus Belonje
May 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Magali LacroixJean-François Huneau
Nov 3, 2012·Journal of Toxicology and Environmental Health. Part a·Dale J Marino
Jan 19, 2012·Journal of Toxicology and Environmental Health. Part a·Dale J Marino
Feb 26, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Farida Louise Assem, Leonard Stephen Levy
Aug 19, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M HarwoodT C Lines

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