New-onset adult asthma in relation to damp and moldy workplaces.

International Archives of Occupational and Environmental Health
Kirsi KarvalaH Nordman

Abstract

Damp and moldy indoor environments aggravate pre-existing asthma. Recent meta-analyses suggest that exposure to such environments may also induce new-onset asthma. We assessed the probability of molds being the cause of asthma in a patient series examined because of respiratory symptoms in relation to workplace dampness and molds. Altogether 694 such patients had been clinically assessed between 1995 and 2004. According to their histories, they had all been exposed to molds at work and had suffered from work-related lower respiratory symptoms. The investigations had included specific inhalation challenge (SIC) tests with mold extracts and serial peak expiratory flow (PEF) recordings. Using internationally recommended diagnostic criteria for occupational asthma (OA), we categorized the patients into three groups: probable, possible, and unlikely OA (156, 45, and 475 patients, respectively). The clinical details of 258 patients were analyzed, and their levels of microbial exposure were evaluated. The agreement between the serial PEF recordings and SIC tests (both being either positive or negative) was 56%. In the group of probable OA, mold sensitization was found in 20%. The level of exposure and sensitization to molds was associ...Continue Reading

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Citations

Jul 20, 2011·International Archives of Occupational and Environmental Health·Kirsi KarvalaHenrik Nordman
Feb 3, 2011·Occupational Medicine·R MäkeläT Hannu
Nov 14, 2013·PloS One·Rachel I AdamsThomas D Bruns
Dec 5, 2012·International Archives of Occupational and Environmental Health·Kirsi KarvalaJukka Uitti
Nov 30, 2013·Otolaryngologic Clinics of North America·Rachel GeorgopoulosElina Toskala
Oct 25, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S KespohlM Raulf-Heimsoth
Apr 5, 2018·International Journal of Environmental Research and Public Health·Katja TähtinenHeidi Salonen
Jan 25, 2019·American Journal of Industrial Medicine·Pål GraffUlf Flodin
May 18, 2018·European Respiratory Review : an Official Journal of the European Respiratory Society·Denis CaillaudUNKNOWN mould ANSES working group
Sep 16, 2017·Allergy, Asthma & Immunology Research·Jung Hye ByeonYoung Yoo
Feb 19, 2014·Current Opinion in Allergy and Clinical Immunology·Mohamed F JeebhayNicole le Moual
Feb 28, 2019·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Yifan ShanGuicheng Zhang

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