New-onset diabetes after pancreatoduodenectomy: A systematic review and meta-analysis

Surgery
Lianne ScholtenMarc G Besselink

Abstract

Pancreatoduodenectomy may lead to new-onset diabetes mellitus, also known as type 3c diabetes, but the exact risk of this complication is unknown. The aim of this review was to assess the risk of new-onset diabetes mellitus after pancreatoduodenectomy. A literature search was performed in PubMed, Embase (Ovid), and the Cochrane Library for English articles published from March 1993 until March 2017 (PROSPERO registry number: CRD42016039784). Studies reporting on the risk of new-onset diabetes mellitus after pancreatoduodenectomy were included. For meta-analysis, studies were pooled using the random-effects model. All studies were appraised according to the Newcastle-Ottawa Scale. After screening 1,523 studies, 22 studies involving 1,121 patients were eligible. The mean weighted overall proportion of new-onset diabetes mellitus after pancreatoduodenectomy was 16% (95% confidence interval, 12%-20%). We found no significant difference in risk of new-onset diabetes mellitus when pancreatoduodenectomy was performed for nonmalignant disease after excluding patients with chronic pancreatitis (19% risk; 95% confidence interval, 7%-43%; 6 studies) or for malignant disease (22% risk; 95% confidence interval, 14%-32%; 11 studies), P = .71...Continue Reading

Citations

Sep 19, 2019·Nature Reviews. Gastroenterology & Hepatology·Nadine C M van HuijgevoortMarc G Besselink
Dec 8, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Bobby K PrangerUNKNOWN Dutch Pancreatic Cancer Group
Dec 15, 2020·The American Journal of Medicine·Qurat Ul Ain Riaz SipraMohamad Bassam Sonbol
Jan 6, 2021·International Journal of Surgery Case Reports·Ayato ObanaTatsushi Suwa
May 19, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Anouk E J LatensteinUNKNOWN Dutch Pancreatic Cancer Group
Aug 3, 2021·Annals of Gastroenterological Surgery·Daisaku YamadaMasato Sakon

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