New-onset epilepsy in women with first time seizures during pregnancy.

Seizure : the Journal of the British Epilepsy Association
Grace J MaEmily Johnson

Abstract

In women with epilepsy, seizure frequency and severity can be affected during pregnancy by factors such as changes in ASD (anti-seizure drug) metabolism, changes in hormone levels, and medication compliance. Some women with epilepsy experience seizure worsening during pregnancy, while others have an improvement. Most epileptic seizures during pregnancy occur in women with pre-existing epilepsy. Rarely, women develop new-onset seizure-like episodes concerning for epileptic seizures during pregnancy, posing a diagnostic and therapeutic challenge for the physician. To determine the frequency of new-onset seizures during pregnancy and the clinical course of those with new seizures, we performed a retrospective study of all women with concomitant diagnoses of pregnancy and seizures (excluding eclampsia) at the Johns Hopkins Medical Institutions over a five-year period. We calculated the frequency of events concerning for seizures during pregnancy, including first-lifetime events, and classified these events as epileptic seizures or as seizure mimics. For those with epileptic seizures, we followed up with the patient to determine whether seizures recurred in or after pregnancy, and whether treatment with anti-seizure medication was i...Continue Reading

References

Jan 1, 1987·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·R E Ramsay
Apr 16, 2002·Journal of Medical Genetics·S Shorvon
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May 4, 2012·Neurology·S Hernández-DíazUNKNOWN North American AED Pregnancy Registry
Jun 7, 2013·Continuum : Lifelong Learning in Neurology·Page B Pennell

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Citations

Aug 18, 2020·Seizure : the Journal of the British Epilepsy Association·Shahla MelikovaSharif Magalov

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