New-onset type 1 diabetes in Finnish children during the COVID-19 pandemic.

Archives of Disease in Childhood
Heli SalmiMikael Knip

Abstract

Viral infections may trigger type 1 diabetes (T1D), and recent reports suggest an increased incidence of paediatric T1D and/or diabetic ketoacidosis (DKA) during the COVID-19 pandemic. To study whether the number of children admitted to the paediatric intensive care unit (PICU) for DKA due to new-onset T1D increased during the COVID-19 pandemic, and whether SARS-CoV-2 infection plays a role. This retrospective cohort study comprises two datasets: (1) children admitted to PICU due to new-onset T1D and (2) children diagnosed with new-onset T1D and registered to the Finnish Pediatric Diabetes Registry in the Helsinki University Hospital from 1 April to 31 October in 2016-2020. We compared the incidence, number and characteristics of children with newly diagnosed T1D between the prepandemic and pandemic periods. The number of children admitted to PICU due to new-onset T1D increased from an average of 6.25 admissions in 2016-2019 to 20 admissions in 2020 (incidence rate ratio [IRR] 3.24 [95% CI 1.80 to 5.83]; p=0.0001). On average, 57.75 children were registered to the FPDR in 2016-2019, as compared with 84 in 2020 (IRR 1.45; 95% CI 1.13 to 1.86; p=0.004). 33 of the children diagnosed in 2020 were analysed for SARS-CoV-2 antibodies,...Continue Reading

References

Jan 8, 2010·Diabetes Research and Clinical Practice·Noaman M HasanMichael J MacDonald
Sep 6, 2011·European Journal of Endocrinology·Anne HekkalaUNKNOWN Finnish Paediatric Diabetes Register
Jul 5, 2012·Cold Spring Harbor Perspectives in Medicine·Mikael Knip, Olli Simell
Nov 13, 2017·Biochemical and Biophysical Research Communications·Ting-Ting ShiJin-Kui Yang
Jan 31, 2020·The Lancet. Diabetes & Endocrinology·Jill M NorrisLars C Stene
Mar 27, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Anu HaveriCarita Savolainen-Kopra
Mar 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juanjuan ZhaoZheng Zhang
Apr 13, 2020·The Lancet Child & Adolescent Health·Marzia LazzeriniGianluca Trobia
Apr 18, 2020·Current Protocols in Microbiology·Daniel StadlbauerFlorian Krammer
May 14, 2020·Nature Medicine·Fatima AmanatFlorian Krammer
May 22, 2020·The Journal of Pediatrics·Valentino CherubiniDavid M Maahs
Jun 13, 2020·The New England Journal of Medicine·Francesco RubinoEric Renard
Jun 24, 2020·Acta Paediatrica·Devi DayalMuralidharan Jayashree
Jul 21, 2020·Pediatric Diabetes·Nancy Samir ElbarbaryAndrea Enzo Scaramuzza
Jul 24, 2020·JAMA : the Journal of the American Medical Association·Clemens KamrathReinhard W Holl
Aug 12, 2020·Diabetes Care·Ivana RabboneUNKNOWN Diabetes Study Group of the Italian Society for Pediatric Endocrinology and Diabetes
Aug 23, 2020·Diabetes Care·Sascha René TittelUNKNOWN DPV Initiative
Sep 23, 2020·Journal of Paediatrics and Child Health·Gabby AtlasMichele A O'Connell
Oct 2, 2020·Diabetes Care·Anna ParviainenUNKNOWN Finnish Pediatric Diabetes Register
Oct 7, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·C LawrenceP Lopez
Oct 22, 2020·Science·Ludovico Cantuti-CastelvetriMikael Simons
Nov 25, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Ali RostamiRobin B Gasser
Jul 1, 2021·BMJ Paediatrics Open·Heini Harve-RytsäläHeli Salmi

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.