New-onset type 2 diabetes mellitus--A high-risk group suitable for the screening of pancreatic cancer?

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Dóra IllésLászló Czakó

Abstract

Type 2 diabetes mellitus is widely considered to be associated with pancreatic cancer. To determine the incidence of pancreatic cancer in new-onset type 2 diabetic patients by measuring the serum level of CA 19-9 and performing abdominal ultrasonography (US). Consecutive type 2 diabetic patients in whom diabetes was diagnosed within 36 months were included in this prospective study. Serum CA 19-9 measurement and US were performed in all patients. If any of two was positive, abdominal computer tomography (CT) was carried out. Endoscopic ultrasound-guided fine needle aspiration or direct surgical referral was performed on patients with CT-identified lesions. A total of 115 patients were enrolled. CA 19-9 was elevated in 10 patients but pancreatic cancer diagnosed in neither of them. Pancreatic cancer was revealed by morphological means in three patients without elevated CA 19-9 level. The sensitivity, specificity, positive-, negative predictive values and validity were 0%, 90.4%, 0%, 97.9% and 87.9% for CA 19-9, 66.7%, 100%, 100%, 99% and 99% for US, respectively. The value of the Standardized Incidence Ratio for pancreatic cancer in new-onset type-2 diabetic patients was 198.6 (95% CI = 6.25-46.9). The prevalence of pancreatic c...Continue Reading

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Citations

Aug 23, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Erica DugnaniLorenzo Piemonti
Aug 25, 2016·Acta Diabetologica·Erica DugnaniLorenzo Piemonti
Mar 9, 2017·Nutrients·Taylor M GillilandGeorge Van Buren
Oct 17, 2018·Pancreas·Anirban MaitraUNKNOWN Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)
Feb 16, 2019·Diagnostics·Atsushi KannoMasayuki Kitano
Aug 24, 2019·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Min Kyu Jung
Feb 23, 2019·World Journal of Gastrointestinal Oncology·Alexander Jp FultonJuan W Valle
Aug 14, 2020·Diagnostics·Suguru MizunoKazuhiko Koike
May 19, 2018·Gastroenterology·Ayush SharmaSuresh T Chari

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