New opportunities for identification and reduction of coronary risk: treatment of vulnerable patients, arteries, and plaques

Journal of the American College of Cardiology
James E MullerJagat Narula

Abstract

Advances in the understanding of the role of vulnerable plaque in the causation of coronary events, coupled with novel diagnostic and therapeutic approaches, create a new opportunity for progress against cardiovascular disease. The recognition that non-flow-limiting plaques often produce cardiac events has led to the development of invasive and non-invasive methods to identify such plaques prospectively. Treatments such as stenting, photodynamic therapy, and novel pharmaceutical agents are under consideration as methods to stabilize the vulnerable plaques and patients that might be detected, thereby enhancing both primary and secondary prevention. Despite the promise of the field, many issues remain to be resolved, including the focality versus systemic nature of the atherosclerotic process, the ability of detectors to identify the target for which they were developed and prove that such a target is linked to clinical events, and the efficacy of specific therapy. If vulnerable plaques and patients can be successfully identified and treated, there will be immense clinical benefits, accompanied by cost savings.

References

Aug 1, 1995·Circulation·E FalkV Fuster
Mar 1, 1994·Journal of the American College of Cardiology·J E MullerG H Tofler
Aug 18, 2001·Circulation Research·Z A Fayad, V Fuster
Oct 12, 2001·The American Journal of Cardiology·P Libby
Mar 12, 2002·JAMA : the Journal of the American Medical Association·Rajendra H MehtaUNKNOWN GAP Steering Committee of the American College of Cardiology
Mar 10, 2004·The New England Journal of Medicine·Christopher P CannonUNKNOWN Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators
Aug 13, 2004·The New England Journal of Medicine·Pim van der HarstDirk J van Veldhuisen
Aug 27, 2004·Circulation Journal : Official Journal of the Japanese Circulation Society·Fumio InoueTakahisa Uchiyama
Jun 10, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ahmed TawakolAlan J Fischman
Jun 29, 2005·Circulation·Peter Libby, Pierre Theroux
Apr 25, 2006·Journal of the American College of Cardiology·Renu VirmaniFrank D Kolodgie
Apr 25, 2006·Journal of the American College of Cardiology·Erling Falk

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Citations

Jul 8, 2008·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·D E GoertzA F W van der Steen
Jan 10, 2013·Current Atherosclerosis Reports·Saurabh SanonRobert Chilton
Oct 31, 2012·Cardiovascular Intervention and Therapeutics·Sadako MotoyamaYukio Ozaki
Aug 13, 2008·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Amin KatouzianStéphane G Carlier
Jul 31, 2007·Journal of the American College of Cardiology·Sadako MotoyamaJagat Narula
May 11, 2007·Atherosclerosis·Konstantinos ToutouzasChristodoulos Stefanadis
Oct 25, 2006·Current Cardiology Reports·Benjamin J W Chow, John P Veinot
Sep 1, 2015·Pharmacological Reports : PR·Szczepan ZapotocznyMaria Nowakowska
Mar 8, 2011·Current Cardiovascular Imaging Reports·Amr Abdelbaky, Ahmed Tawakol

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