New options and old dilemmas in the treatment of patients with advanced colorectal cancer

Annals of Oncology : Official Journal of the European Society for Medical Oncology
C J A Punt

Abstract

With more data on the use of oxaliplatin and irinotecan available, and the recent approval of two signal transduction inhibitors for patients with advanced colorectal cancer, there are now many treatment options to choose from. From the current regimens no straightforward choice can be made that provides any patient with the optimal chance for prolonged survival with the least side-effects. The current data concerning timing and duration of chemotherapy, combination or sequential therapy, preference of agents for first-line treatment, oral fluoropyrimidines, neo-adjuvant chemotherapy for irresectable liver metastases, and the use of signal transduction inhibitors are reviewed.

References

Sep 28, 2000·The New England Journal of Medicine·L B SaltzL L Miller
Feb 28, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C J A PuntL Hammershaimb
Mar 29, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Markus M BornerArnaud D Roth
Apr 30, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T Ruers, R P Bleichrodt
Jun 12, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J CassidyUNKNOWN Capecitabine Colorectal Cancer Study Group
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Yves DouillardSteven E Benner
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James CarmichaelChristophe Martin
Sep 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jürgen DunstStefan Frings
Feb 14, 2003·Lancet·T S MaughanUNKNOWN Medical Research Council Colorectal Cancer Group
Jun 18, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Adam
Aug 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claus RödelRolf Sauer
Aug 29, 2003·Lancet·Françoise Meunier, Denis Lacombe
Sep 5, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ZeuliF Cognetti
Sep 10, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew P GoetzRichard M Goldberg
Sep 10, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mace L Rothenberg, Jordan D Berlin
Sep 10, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C-H KöhneUNKNOWN European Organization of Research and Treatment of Cancer Gastrointestinal Group Study 40952
Dec 6, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christophe TournigandAimery de Gramont
Dec 11, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard M GoldbergSteven R Alberts
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard B SaltzRobert J Mayer
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Axel GrotheyHans-Joachim Schmoll
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem

❮ Previous
Next ❯

Citations

Jul 14, 2010·Cancer Chemotherapy and Pharmacology·Manabu ShiozawaSoichiro Morinaga
Feb 18, 2009·International Journal of Colorectal Disease·Emmanuel MitryPhilippe Rougier
May 14, 2005·Critical Reviews in Oncology/hematology·Andrea Mancuso, Cora N Sternberg
Sep 10, 2011·The Lancet Oncology·Michel DucreuxUNKNOWN Fédération Francophone de Cancérologie Digestive (FFCD) 2000–05 Collaborative Group
Jan 20, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C PostmaG A Meijer
Oct 29, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J TolC J A Punt
Jan 30, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L B J van IerselH Gelderblom
Nov 23, 2006·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Lioe-Fee de Geus-OeiWim J G Oyen
Jul 11, 2012·International Journal of Surgical Oncology·Georgios Tsoulfas, Manousos-Georgios Pramateftakis
Jan 1, 2009·OncoTargets and Therapy·Giuseppe ToniniDaniele Santini
Nov 1, 2008·Journal of Cancer Research and Clinical Oncology·Manabu ShiozawaYukio Sugimasa
Oct 16, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D CunninghamJ Cassidy
Oct 27, 2006·Expert Opinion on Emerging Drugs·Bruno VincenziGiuseppe Tonini
Jun 15, 2007·Expert Opinion on Pharmacotherapy·Marieke KrolCornelis J A Punt
Dec 23, 2015·International Journal of Molecular Sciences·Manveen K Sethi, Susan Fanayan
Dec 7, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Nadya PostriganovaBjørn Edwin
Oct 10, 2009·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Dries VandeweyerRobert T A Padbury
Apr 20, 2010·Clinical Therapeutics·Jolien Tol, Cornelis J A Punt
Sep 25, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Miriam Koopman, Cornelis J A Punt
May 22, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Miriam KoopmanCornelis J Punt
May 29, 2007·Clinical Colorectal Cancer·Stephen M ColganPierre Major
Jun 6, 2007·Surgical Oncology·Bradley J Champagne, Conor P Delaney
Jan 9, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A P Schouten van der VeldenT J M Ruers
Jun 10, 2015·Molecular Aspects of Medicine·Shuang Yin ZhangBassel F El-Rayes
Nov 26, 2008·Journal of Magnetic Resonance Imaging : JMRI·Tammy L KalberSimon P Robinson
Oct 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Hanneke W M van LaarhovenAlbert J van der Kogel
Jan 1, 2014·European Journal of Cancer Care·C W M van GilsC A Uyl-de Groot
Nov 12, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N KnijnC J A Punt
Oct 21, 2005·Clinical Journal of Oncology Nursing·Pamela Hallquist VialeLaura Zitella

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Richard M GoldbergSteven R Alberts
The New England Journal of Medicine
Herbert I HurwitzFairooz F Kabbinavar
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Christophe TournigandAimery de Gramont
© 2021 Meta ULC. All rights reserved