New options for treatment of candidaemia in critically ill patients

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Markus RuhnkeG Kofla

Abstract

Bloodstream infections caused by Candida spp. are increasingly recognised in critically ill adult and paediatric individuals, with significant associated morbidity and mortality. Candida albicans is the single most common fungal species to cause nosocomial infections. However, non-C. albicans spp., including Candida glabrata and Candida krusei, which are less susceptible to fluconazole, have become more common. Until the 1980s, the therapeutic possibilities for invasive candidosis were limited to amphotericin B, but with the advent of new antifungal agents, such as azoles and echinocandins, less toxic therapeutic options have become available and there are now possibilities for prevention and optimised therapy for documented Candida infections. In this review, the currently available options for the treatment of candidaemia and invasive candidosis are discussed with regard to the role of liposomal amphotericin B in comparison with the echinocandins and azoles.

References

Dec 1, 1988·Archives of Internal Medicine·S B WeyR P Wenzel
Aug 1, 1996·The American Journal of Medicine·E J AnaissieG P Bodey
Nov 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E J AnaissieG P Bodey
Jun 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D PittetR P Wenzel
Oct 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A S KaoR A Hajjeh
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J R WingardJ Lister
Mar 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D W BatesR Platt
Nov 14, 2001·The American Journal of Medicine·S HarbarthM H Samore
Jun 20, 2002·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T BüchnerUNKNOWN Panel of Interdisciplinary Investigators
Aug 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W E TrickUNKNOWN National Nosocomial Infections Surveillance System Hospitals
Dec 20, 2002·The New England Journal of Medicine·Jorge Mora-DuarteUNKNOWN Caspofungin Invasive Candidiasis Study Group
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
May 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John H RexUNKNOWN National Institute of Allergy and Infectious Diseases Mycoses Study Group
Jul 29, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Luis Ostrosky-ZeichnerStuart H Cohen
Sep 12, 2003·Emerging Infectious Diseases·Eira PoikonenPetri Ruutu
Oct 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Olafur GudlaugssonDaniel Diekema
Dec 31, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasUNKNOWN Infectious Diseases Society of America
Nov 9, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Rakesh K MondalJayashree M
Dec 2, 2004·Indian Journal of Pediatrics·Sunit C SinghiArunaloke Chakrabarti
Mar 15, 2005·Scandinavian Journal of Infectious Diseases·Lena Rós AsmundsdóttirMagnús Gottfredsson
Apr 6, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James I Ito, Roya Hooshmand-Rad
Apr 9, 2005·Journal of Clinical Microbiology·Benito AlmiranteUNKNOWN Barcelona Candidemia Project Study Group
Jun 28, 2005·Current Molecular Medicine·R C Matthews, J P Burnie
Jul 26, 2005·The Journal of Antimicrobial Chemotherapy·Kevin B LauplandSameer Elsayed
Apr 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jose A VazquezRandi Isaacs
Apr 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jan PachlUNKNOWN Mycograb Invasive Candidiasis Study Group
Jun 8, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kevin W GareyDavid T Bearden
Jun 8, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andre N SofairScott K Fridkin
May 8, 2007·Lancet·Ernst-Rüdiger KuseUNKNOWN Micafungin Invasive Candidiasis Working Group
Jun 15, 2007·The New England Journal of Medicine·Annette C ReboliUNKNOWN Anidulafungin Study Group
Sep 7, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter G PappasDonald N Buell
Sep 18, 2007·Journal of Critical Care·Mark J DiNubileNicholas A Kartsonis

❮ Previous
Next ❯

Citations

Feb 13, 2013·Clinical Drug Investigation·João F Lacerda, Carlos Meneses Oliveira
May 13, 2009·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Blase BillackCesar Lau-Cam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.