New options in the treatment of locally advanced head and neck cancer: role for induction chemotherapy

Cancer Treatment Reviews
Juan J CruzEmilio Fonseca

Abstract

Advanced locoregional disease is the most frequent clinical situation in Head and Neck cancer. The standard of care for most clinicians is a multidisciplinary treatment with concomitant chemotherapy plus radiotherapy (CRT). However, retrospective studies have shown that in patients treated with CRT there was a relative increase in systemic relapse due to a lack of systemic control. For this reason a renewed interest has appeared for the incorporation of induction chemotherapy in the treatment of locally advanced Head and Neck Cancer. Furthermore new combination regimens with taxanes have shown to be more active than the classical cisplatin and 5-fluorouracil induction regimen. For these reasons ongoing trials are comparing induction chemotherapy followed by chemoradiotherapy with chemoradiotherapy alone. In this review, we will discuss the currently available data that support the design of these clinical trials as well as the future role of new agents in this clinical situation.

References

Feb 24, 2001·British Journal of Cancer·C DomengeUNKNOWN French Groupe d'Etude des Tumeurs de la Tête et du Cou (GETTEC)
Jan 5, 2002·The New England Journal of Medicine·A ForastiereD Sidransky
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David J AdelsteinMarjorie A Carroll
Sep 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mitchell MachtayUNKNOWN Penn Cancer Center Clinical Trials Group
Oct 16, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R HittH Cortés-Funes
Dec 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David J AdelsteinArlene A Forastiere
Jan 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Everett E VokesDaniel J Haraf
Jun 25, 2003·Expert Review of Anticancer Therapy·Robert I HaddadMarshall R Posner
Dec 3, 2003·The New England Journal of Medicine·Arlene A ForastiereJay Cooper
Dec 6, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fabrice DenisGilles Calais
Apr 5, 2005·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J-P PignonJ Bourhis
Jul 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstMerrill S Kies
Jul 16, 2005·CA: a Cancer Journal for Clinicians·Snehal G Patel, Jatin P Shah
Nov 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ricardo HittHernán Cortés-Funes
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara BurtnessUNKNOWN Eastern Cooperative Oncology Group
Feb 10, 2006·The New England Journal of Medicine·James A BonnerK Kian Ang
Oct 26, 2007·The New England Journal of Medicine·Jan B VermorkenUNKNOWN EORTC 24971/TAX 323 Study Group
Oct 26, 2007·The New England Journal of Medicine·Marshall R PosnerUNKNOWN TAX 324 Study Group

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Citations

Jan 30, 2016·Clinical Oral Investigations·Cheng-Chang YehYi-Ting Deng
Aug 24, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Cristiane Cademartori DanesiMauricio Lehmann
Jan 20, 2010·Mutation Research·Cristiane Cademartori DanesiMauricio Lehmann
Jun 19, 2009·Clinical Oncology : a Journal of the Royal College of Radiologists·O MatzingerM Ozsahin
Dec 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edwin P HuiAnthony T Chan
Apr 14, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery

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