New orally administered antihyperglycemic agents for the management of patients with type ii diabetes and the syndrome of insulin resistance.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
S V Edelman

Abstract

To describe several newly developed orally administered antidiabetic drugs, which are effective for type II diabetes. Detailed clinical information about three types of antihyperglycemic agents--carbohydrase inhibitors, biguanides, and thiazolidinediones--is presented. Miglitol and acarbose, two a-glucosidase inhibitors, effectively reduce postprandial blood glucose values and do not cause hypoglycemia. The biguanide metformin has been shown to suppress hepatic glucose production, augment glucose uptake, and enhance insulin action in peripheral tissues. Metformin is effective alone or in combination with other orally administered antidiabetic agents or insulin. A new class of antidiabetic agents called the thiazolidinediones (not yet available for clinical use) apparently works by mainly reducing insulin resistance in skeletal muscle. The most extensively studied drug in this category is troglitazone. Carbohydrase inhibitors as well as biguanides may be useful in patients with the insulin resistance syndrome, especially those with obesity, hypertension, and hyperinsulinemia. Because of the development of new antihyperglycemic agents for oral administration, the need for insulin injections in patients with type II diabetes will ...Continue Reading

References

Apr 1, 1992·Diabetes Care·P J KingmaA C Nieuwenhuijzen Kruseman
Jun 1, 1992·Diabetes Care·C J Bailey
Dec 1, 1991·The Journal of Clinical Endocrinology and Metabolism·R A DeFronzoD C Simonson
Apr 1, 1991·Diabetes Care·T L DornanR B Tattersall
Oct 1, 1990·Metabolism: Clinical and Experimental·T P CiaraldiK A Heidenreich
Feb 1, 1988·Metabolism: Clinical and Experimental·M W Stolar
Jan 1, 1988·Metabolism: Clinical and Experimental·D Y JonesP P Nair
Nov 3, 1994·The New England Journal of Medicine·J J NolanJ Olefsky
Jan 1, 1993·Metabolism: Clinical and Experimental·S YoshiokaH Horikoshi

❮ Previous
Next ❯

Citations

Nov 25, 2000·Metabolism: Clinical and Experimental·J D SparksC E Sparks

❮ Previous
Next ❯

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Related Papers

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
M B Davidson
Journal of Clinical Pharmacy and Therapeutics
K Landin-Wilhelmsen
© 2022 Meta ULC. All rights reserved