Abstract
To describe several newly developed orally administered antidiabetic drugs, which are effective for type II diabetes. Detailed clinical information about three types of antihyperglycemic agents--carbohydrase inhibitors, biguanides, and thiazolidinediones--is presented. Miglitol and acarbose, two a-glucosidase inhibitors, effectively reduce postprandial blood glucose values and do not cause hypoglycemia. The biguanide metformin has been shown to suppress hepatic glucose production, augment glucose uptake, and enhance insulin action in peripheral tissues. Metformin is effective alone or in combination with other orally administered antidiabetic agents or insulin. A new class of antidiabetic agents called the thiazolidinediones (not yet available for clinical use) apparently works by mainly reducing insulin resistance in skeletal muscle. The most extensively studied drug in this category is troglitazone. Carbohydrase inhibitors as well as biguanides may be useful in patients with the insulin resistance syndrome, especially those with obesity, hypertension, and hyperinsulinemia. Because of the development of new antihyperglycemic agents for oral administration, the need for insulin injections in patients with type II diabetes will ...Continue Reading
References
Apr 1, 1992·Diabetes Care·P J KingmaA C Nieuwenhuijzen Kruseman
Feb 1, 1992·Diabetes Care·S L SuterJ M Olefsky
Jun 1, 1992·Diabetes Care·C J Bailey
Nov 1, 1991·Diabetes Care·Y IwamotoI Shiraishi
Feb 1, 1991·Journal of Internal Medicine·K LandinU Smith
Dec 1, 1991·The Journal of Clinical Endocrinology and Metabolism·R A DeFronzoD C Simonson
Apr 1, 1991·Diabetes Care·T L DornanR B Tattersall
Oct 1, 1990·Metabolism: Clinical and Experimental·T P CiaraldiK A Heidenreich
May 1, 1990·Atherosclerosis·J SchneiderH Kaffarnik
Aug 1, 1990·Diabetes Care·L S Hermann
Jan 1, 1990·Diabetes Care·M S WuG M Reaven
Nov 1, 1988·Diabetes·T FujiwaraH Horikoshi
Feb 1, 1988·Metabolism: Clinical and Experimental·M W Stolar
Jan 1, 1988·Metabolism: Clinical and Experimental·D Y JonesP P Nair
Oct 1, 1994·Diabetes Care·J JeppesenG M Reaven
Oct 1, 1994·Diabetes Care·L S HermannA Melander
Nov 3, 1994·The New England Journal of Medicine·J J NolanJ Olefsky
Jan 1, 1994·Diabetes Care·P S JohnstonA Krol
Jul 1, 1993·Diabetes Care·J C ChanR J Walden
Jan 1, 1993·Diabetes Care·R R HenryH S Glauber
Jan 1, 1993·Metabolism: Clinical and Experimental·S YoshiokaH Horikoshi
Apr 1, 1993·Diabetes Care·D K Nagi, J S Yudkin