PMID: 930755Oct 1, 1977

New orally effective chromosome derivatives for the treatment of asthma

Agents and Actions
J AugsteinP Sheard

Abstract

Two new chromone derivatives have been identified which possess oral anti-allergic activity in the rat PCA model of immediate hypersensitivity. They may have a wider spectrum of anti-allergic activity than disodium cromoglycate (SCG) since they are effective in in vitro tests involving sensitized basophils, in which SCG is inactive. Both compounds, when given orally, provide relief from experimental and clinical asthma in man.

References

May 24, 1975·Lancet·J F BatchelorJ E Tateson
Jan 1, 1973·International Archives of Allergy and Applied Immunology·E S Assem, M McAllen
Aug 1, 1931·The British Journal of Ophthalmology·N Patterson, H Cairns

Citations

Jul 1, 1983·European Journal of Drug Metabolism and Pharmacokinetics·D A Smith, M G Neale
Jan 1, 1987·International Journal of Immunopharmacology·L J RobichaudR L Adolphson
Jan 1, 1987·International Journal of Immunopharmacology·R L AdolphsonL J Robichaud
Mar 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·B ClarkD V Parke
Dec 1, 1981·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A N FisherD A Smith
Jul 1, 1984·Journal of Pharmaceutical Sciences·M G DavisC A Wilson
Mar 1, 1985·Regulatory Toxicology and Pharmacology : RTP·A J ClarkeD V Parke
Jan 1, 1980·Clinical Allergy·N C ThomsonJ W Kerr
Feb 1, 1986·The Journal of Pathology·W R Roche
Jan 1, 1984·Agents and Actions·M O'Donnell, A F Welton
Jul 1, 1979·British Journal of Pharmacology·B E Hall, S P James

Related Concepts

Metazoa
Asthma
Basophils
Lobar Bronchus Structure
Chromones
Immunoglobulin E
Passive Cutaneous Anaphylaxis
Rats, Laboratory
In Vitro [Publication Type]

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