New palladium(II) and platinum(II) 5,5-diethylbarbiturate complexes with 2-phenylpyridine, 2,2'-bipyridine and 2,2'-dipyridylamine: synthesis, structures, DNA binding, molecular docking, cellular uptake, antioxidant activity and cytotoxicity

Dalton Transactions : an International Journal of Inorganic Chemistry
Ceyda IcselOrhan Buyukgungor

Abstract

Novel palladium(ii) and platinum(ii) complexes of 5,5-diethylbarbiturate (barb) with 2-phenylpyridine (Hppy), 2,2'-bipyridine (bpy) and 2,2'-dipyridylamine (dpya) have been prepared and characterized by elemental analysis, IR, UV-Vis, NMR and ESI-MS. Single-crystal diffraction measurements show that complex consists of binuclear [Pd2(μ-barb-κN,O)2(ppy-κN,C)2] moieties, while complexes are mononuclear, [M(barb-κN)2(L-κN,N')] (L = bpy or dpya). has a composition of [Pt(dpya-κN,N')2][Ag(barb-κN)2]2·4H2O and was assumed to have a structure of [Pt(barb-κN)(Hppy-κN)(ppy-κN,C)]·3H2O. The complexes were found to exhibit significant DNA binding affinity by a non-covalent binding mode, in accordance with molecular docking studies. In addition, complexes and displayed strong binding with supercoiled pUC19 plasmid DNA. Cellular uptake studies were performed to assess the subcellular localization of the selected complexes. A moderate radical scavenging activity of and was confirmed by DPPH and ABTS tests. Complexes , , and showed selectivity against HT-29 (colon) cell line.

References

Jun 1, 1995·Bioorganic & Medicinal Chemistry·D Suh, J B Chaires
Dec 15, 1993·Gene·R Thomas
Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Mar 24, 2000·Archives of Biochemistry and Biophysics·E GalloriL Messori
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·Q HeS J Lippard
Jul 18, 2001·Journal of the American Chemical Society·B OnfeltB Nordén
Feb 14, 1996·Inorganic Chemistry·Kevin J. BarnhamPeter J. Sadler
Oct 24, 2001·Inorganic Chemistry·Matteo CusumanoAntonino Giannetto
Dec 26, 2001·Chemical Reviews·C Orvig, M J Abrams
Aug 15, 2002·Journal of Inorganic Biochemistry·Deborah B ZambleStephen J Lippard
Mar 18, 2004·Oligonucleotides·Jean-Louis Mergny, Laurent Lacroix
Oct 26, 2005·Inorganic Chemistry·Wei LuJacqueline K Barton
Apr 13, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Paul J Dyson, Gianni Sava
Dec 15, 2006·Journal of the American Chemical Society·Seiji KomedaLoren Dean Williams
Nov 9, 2007·Current Opinion in Biotechnology·Rahul Palchaudhuri, Paul J Hergenrother
Dec 25, 2007·Acta Crystallographica. Section A, Foundations of Crystallography·George M Sheldrick
Apr 10, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Venugopal RajendiranMohammad Abdulkader Akbarsha
Apr 11, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Venugopal RajendiranMallayan Palaniandavar
Nov 18, 2008·Journal of Medicinal Chemistry·Zhidong MaUlrich Bierbach
Aug 7, 2009·Journal of Chemical Information and Modeling·Clarisse G Ricci, Paulo A Netz
Jan 13, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Tereza AfratiDimitris P Kessissoglou
Apr 8, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Filitsa DimizaGeorge Psomas
Dec 30, 2010·Current Topics in Medicinal Chemistry·K Benjamin Garbutcheon-SinghJanice R Aldrich-Wright
Mar 31, 2011·Accounts of Chemical Research·Hong-Ke Liu, Peter J Sadler
Mar 1, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·M Dolores SantanaJ Luis Serrano
Jul 25, 2012·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Lee-Fang ChinChew-Hee Ng
Sep 28, 2012·Chemistry : a European Journal·Jian ZhaoZhimei Wang
Mar 12, 2013·DNA and Cell Biology·Ceyda Icsel, Veysel T Yilmaz
Aug 16, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Cecilia Martín SantosJosé Alemán
Nov 18, 2014·Inorganic Chemistry·Jacqueline M HerreraAdoración G Quiroga

❮ Previous
Next ❯

Citations

May 24, 2016·European Journal of Medicinal Chemistry·Enjun GaoMingchang Zhu
Dec 6, 2016·Journal of Biomolecular Structure & Dynamics·Miral V LunagariyaMohan N Patel
Mar 31, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eva Fischer-FodorNatalia Miklášová
Sep 20, 2018·Nucleosides, Nucleotides & Nucleic Acids·Miral V LunagariyaMohan N Patel
Feb 21, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Evgeny Bulatov, Matti Haukka
Jul 18, 2018·International Journal of Molecular Sciences·George K LatsisSotiris K Hadjikakou
Dec 21, 2016·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jebiti HaribabuRamasamy Karvembu
Mar 18, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Mónica Martínez-JunqueraJosé G Pichel
Mar 17, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Jianwei WangXueqi Fu
Feb 20, 2020·Journal of Inorganic Biochemistry·Loredana RicciardiMassimo La Deda
Oct 4, 2020·Bioorganic & Medicinal Chemistry Letters·Sateeshkumar KumbhakonamMuraleedharan K Manheri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.