We present a new technique for acquiring and analyzing intrinsic signal optical images of brain activity, using continuous stimulus presentation and data acquisition. The main idea is to present a temporally periodic stimulus and to analyze the component of the response at the stimulus frequency. Advantages of the new technique include the removal of heart, respiration, and vasomotor artifacts, a dramatic increase in spatial resolution, and a 30-fold or greater reduction in acquisition time. We also present a novel approach to localizing instantaneous neuronal responses using time-reversed stimuli that is widely applicable to brain imaging. To demonstrate the power of the technique, we present high-resolution retinotopic maps of five visual areas in mouse cortex and orientation maps in cat visual cortex.
Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high-resolution optical imaging of intrinsic signals
Uniformity of monkey striate cortex: a parallel relationship between field size, scatter, and magnification factor
Long-range horizontal connections and their role in cortical reorganization revealed by optical recording of cat primary visual cortex
Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: implications for functional brain mapping
Imaging cortical dynamics at high spatial and temporal resolution with novel blue voltage-sensitive dyes
Environmental enrichment extends ocular dominance plasticity into adulthood and protects from stroke-induced impairments of plasticity
Experience-dependent and independent binocular correspondence of receptive field subregions in mouse visual cortex
The structure of pairwise correlation in mouse primary visual cortex reveals functional organization in the absence of an orientation map
Cytoarchitecture of the mouse neocortex revealed by the low-molecular-weight neurofilament protein subunit
Featural and temporal attention selectively enhance task-appropriate representations in human primary visual cortex
A unifying model for activity-dependent and activity-independent mechanisms predicts complete structure of topographic maps in ephrin-A deficient mice
Neurofilament protein and neuronal activity markers define regional architectonic parcellation in the mouse visual cortex
Demonstration of tuning to stimulus orientation in the human visual cortex: a high-resolution fMRI study with a novel continuous and periodic stimulation paradigm.
TrkB kinase is required for recovery, but not loss, of cortical responses following monocular deprivation.
Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation
Functional labeling of neurons and their projections using the synthetic activity-dependent promoter E-SARE
Correlation of hemodynamic and fluorescence signals under resting state conditions in mice's barrel field cortex
Social experience modulates ocular dominance plasticity differentially in adult male and female mice
Effects of PSA Removal from NCAM on the Critical Period Plasticity Triggered by the Antidepressant Fluoxetine in the Visual Cortex
Cortical plasticity induced by transplantation of embryonic somatostatin or parvalbumin interneurons
Environmental enrichment preserved lifelong ocular dominance plasticity, but did not improve visual abilities
Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain
Laminar differences in the orientation selectivity of geniculate afferents in mouse primary visual cortex
Genetic mechanisms control the linear scaling between related cortical primary and higher order sensory areas
MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex
Novel implantable imaging system for enabling simultaneous multiplanar and multipoint analysis for fluorescence potentiometry in the visual cortex
Quantitative map of multiple auditory cortical regions with a stereotaxic fine-scale atlas of the mouse brain
Brain developing: Influences & Outcomes
This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.