New pathogenetic aspects of gut dysmotility in aplastic and hypoplastic desmosis of early childhood

Pediatric Surgery International
William A Meier-RugeA F Schärli

Abstract

The peristaltic movement of the gut is a function of the alternating contraction and relaxation of circular and longitudinal muscles. This movement is induced by a tendon-like connective-tissue net (TCTN) in the circular and longitudinal muscles, which are both rooted in a connective-tissue plexus layer (CTPL). In children with a therapy-resistant aperistaltic or hypoperistaltic syndrome who had normally-developed enteric innervation, a lack of the TCTN in the muscularis propria was observed. Over the last 2 years, 241 children with chronic constipation were investigated histopathologically; 46 children surgically treated by partial resection of the gut or diagnostically investigated by whole-mount biopsy. Fifteen children had a hypoperistalsis syndrome and 3 had an aperistalsis syndrome. All specimens were native and cut in a cryostat. Enteric innervation was examined by acetylcholinesterase and dehydrogenase reactions. The TCTN in the muscularis propria was stained with picric acid/sirius red. In the children with an aperistalsis syndrome, a complete lack of the TCTN in circular and longitudinal muscles was observed. A CTPL was not developed. The children with a hypoperistalsis syndrome had no CTPL, but had a partly-developed...Continue Reading

Citations

Dec 6, 2012·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·William H SeligmanChristopher J Mathias
Jun 19, 2008·Journal of Pediatric Surgery·Daniel J ReillyBridget R Southwell
Oct 10, 2007·Journal of Pediatric Surgery·Takanori NakatsujiSachiyo Suita
Mar 24, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D K Chitkara, C Di Lorenzo
Mar 9, 2011·Best Practice & Research. Clinical Gastroenterology·Charles H Knowles, Gianrico Farrugia
Jan 1, 2004·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Y GálvezJ Herget
Oct 13, 2006·European Journal of Gastroenterology & Hepatology·William A Meier-RugeElisabeth Bruder
Jul 20, 2006·Digestive Diseases·Nader N Youssef, Carlo Di Lorenzo

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