New pathogenetic characters of reticuloendotheliosis virus isolated from Chinese partridge in specific-pathogen-free chickens

Microbial Pathogenesis
Guihua WangZiqiang Cheng

Abstract

Avian reticuloendotheliosis virus (REV) infection can induce a runting syndrome, immunosuppression, acute reticulum cell neoplasia and lymphomas in a variety of domestic and wild birds. To evaluate the pathogenicity and oncogenicity of REV-JX0927 that isolated from Chinese partridge, experimental inoculated day-old specific-pathogen-free (SPF) White Leghorn chickens were examined at regular intervals. The examination procedures included hematology, serology and histopathology; also including immunohistochemistry and apoptosis assay. Body weight, relative immune organs weight and apoptosis assay results revealed that the immunosuppression of infected birds is associated with apoptosis of lymphocytes in lymphoid tissues, especially in thymus induced by REV-JX0927. Hematology and apoptosis assay results showed that the 7th week of post-infection is a critical time point for lymphocytes to be transformed into tumor cells. Histopathology evidences demonstrated that REV-JX0927 induced reticuloendotheliosis at early stage (1 week), and lymphosarcomas at middle stage (after 7 weeks). In addition, squamous-cell carcinoma, adenocarcinoma and aneurysm were found in infected birds. Arteritis was associated with concentration of serum prote...Continue Reading

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Citations

Apr 28, 2016·Archives of Virology·Shao-Lun ZhaiRui-Ai Chen
Aug 14, 2018·Avian Pathology : Journal of the W.V.P.A·Chang GaoShimin Zheng
Jul 1, 2020·BMC Veterinary Research·Xianhua WanYanbin Wang
Sep 26, 2020·Animals : an Open Access Journal From MDPI·Zuamí Villagrán-de la MoraAngélica Villarruel-López
Apr 3, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Ahui XuYanxin Hu

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