New pathogenic insights into rheumatoid arthritis

Current Opinion in Rheumatology
Gurpreet JutleyChristopher D Buckley

Abstract

Rheumatoid arthritis (RA) is a heterogeneous chronic immune-mediated inflammatory disease, associated with significant morbidity and reduced life expectancy. Here, we review recent discoveries; particularly those which have attempted to integrate genome-wide association studies (GWAS) with biological pathways and cell types known to play a role in disease pathology in order to expand our current understanding of the pathogenesis of RA. As the role of stromal cells in the pathogenesis of RA has been reviewed in detail in Current Opinions in Rheumatology, this area will not be covered in this review. Although our understandings of the pathogenic processes that drive disease in RA remain incomplete, remarkable advances over the past year can be highlighted. GWAS have raised awareness of important new risk loci with genes that either are the targets of approved therapies for RA, or involve pathways for drugs that could be repurposed from other disease indications such as cancer. Furthermore, promising strides have been made in predicting the likelihood of developing RA in those at risk using human leukocyte antigen (HLA), smoking, and autoantibody status prediction models. These findings give a fresh insight into RA pathogenesis an...Continue Reading

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Citations

Sep 19, 2015·Molecular Nutrition & Food Research·María Angeles RosilloCatalina Alarcón-de-la-Lastra
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Jun 1, 2021·Frontiers in Pharmacology·Pan Lin XinCheng Wen Dan
Jul 4, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wenjing ZhaiJianfeng Yi
Dec 10, 2017·Best Practice & Research. Clinical Rheumatology·Gurpreet Singh JutleyKarim Raza

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Methods Mentioned

BETA
genotyping
histone acetylation

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