New perspective of ClC-Kb/2 Cl- channel physiology in the distal renal tubule

American Journal of Physiology. Renal Physiology
Oleg ZaikaOleh Pochynyuk

Abstract

Since its identification as the underlying molecular cause of Bartter's syndrome type 3, ClC-Kb (ClC-K2 in rodents, henceforth it will be referred as ClC-Kb/2) is proposed to play an important role in systemic electrolyte balance and blood pressure regulation by controlling basolateral Cl(-) exit in the distal renal tubular segments from the cortical thick ascending limb to the outer medullary collecting duct. Considerable experimental and clinical effort has been devoted to the identification and characterization of disease-causing mutations as well as control of the channel by its cofactor, barttin. However, we have only begun to unravel the role of ClC-Kb/2 in different tubular segments and to reveal the regulators of its expression and function, e.g., insulin and IGF-1. In this review we discuss recent experimental evidence in this regard and highlight unexplored questions critical to understanding ClC-Kb/2 physiology in the kidney.

References

Apr 1, 1975·The Journal of Clinical Investigation·R A DeFronzoP J Davis
Jan 1, 1987·The American Journal of Physiology·L RossettiR DeFronzo
Jan 1, 1995·The Journal of Clinical Investigation·S UchidaF Marumo
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·S KieferleT J Jentsch
May 12, 1998·The American Journal of Physiology·R D RecordB L Blazer-Yost
Sep 4, 1998·The American Journal of Medicine·L M Guay-Woodford
Apr 13, 1999·The American Journal of Physiology·M YoshikawaF Marumo
Jun 1, 2000·The Journal of Biological Chemistry·S Waldegger, T J Jentsch
Sep 21, 2000·American Journal of Physiology. Renal Physiology·D H Ellison
Aug 11, 2001·Science·F H WilsonR P Lifton
Jul 12, 2002·Pflügers Archiv : European journal of physiology·Siegfried WaldeggerHannsjörg W Seyberth
Aug 9, 2002·American Journal of Physiology. Renal Physiology·Craig B WodaLisa M Satlin
Aug 15, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jane J Kim, Domenico Accili
Mar 22, 2003·Science·Raimund DutzlerRoderick MacKinnon
Apr 2, 2003·The Journal of General Physiology·Stéphane LourdelJacques Teulon
Apr 24, 2003·American Journal of Physiology. Renal Physiology·Heino Velázquez, Teresa Silva
May 23, 2003·Histochemistry and Cell Biology·Atsushi HayamaShinichi Uchida
Dec 17, 2003·Kidney International·Nikola JeckSiegfried Waldegger
Jan 14, 2004·The Journal of General Physiology·Alessio AccardiChristopher Miller
Feb 27, 2004·Nature·Alessio Accardi, Christopher Miller
Feb 16, 2005·Annual Review of Physiology·Shinichi Uchida, Sei Sasaki
Jul 22, 2005·Nature·Alessandra Picollo, Michael Pusch
Jan 13, 2006·American Journal of Physiology. Renal Physiology·Antoine NissantJacques Teulon
Jun 21, 2006·Nephron. Physiology·Robert Kleta, Detlef Bockenhauer
Jul 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ute SchollChristoph Fahlke
Apr 20, 2007·Journal of the American Society of Nephrology : JASN·Alexander StaruschenkoJames D Stockand
Sep 5, 2007·Biochemical and Biophysical Research Communications·Masato TajimaShinichi Uchida
Mar 1, 2008·Critical Reviews in Biochemistry and Molecular Biology·Thomas J Jentsch
Mar 28, 2008·American Journal of Physiology. Renal Physiology·Sahran LachhebMarc Paulais

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Citations

Aug 31, 2016·The Journal of General Physiology·Charles S Wingo, James D Stockand
Mar 31, 2017·American Journal of Physiology. Renal Physiology·Lijun WangWen-Hui Wang
May 31, 2018·Physiological Reviews·Thomas J Jentsch, Michael Pusch
Mar 14, 2019·Current Opinion in Nephrology and Hypertension·Aylin R Rodan
Nov 15, 2017·Pflügers Archiv : European journal of physiology·Viktor N TomilinOleh Pochynyuk
May 23, 2019·Molecular Medicine Reports·Yanhan LiYanling Yang
Oct 8, 2019·American Journal of Physiology. Renal Physiology·Elena IsaevaAlexander Staruschenko
Apr 20, 2018·Proceedings of the National Academy of Sciences of the United States of America·Anna K KosterMerritt Maduke
Feb 14, 2018·Endocrine-related Cancer·Antonio De la Vieja, Pilar Santisteban
Jul 19, 2019·Clinical and Experimental Nephrology·Naohiro NomuraShinichi Uchida
Jan 5, 2021·Clinical Kidney Journal·Kuang-Yu WeiEwout J Hoorn

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