New perspectives in antiemetic treatment

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
J Herrstedt

Abstract

Though antiemetic therapy has improved markedly in the past 15 years, patients still regard nausea and vomiting as two of the most distressing adverse events during chemotherapy. A major progress was the development of the serotonin3 (5-HT3) receptor antagonists. A possible antiemetic effect, achieved by interference with the "serotonergic system", is not restricted to antagonism at 5-HT3 receptors, however, but also includes agonism at 5-HT1A and 5-HT2 receptors, and serotonin synthesis inhibitors. The number of receptors thought to be involved in the emetic reflex has been augmented by neurokinin1 receptors with substance P as the preferred ligand. Animal studies have demonstrated a broad antiemetic profile of substance P antagonists. The somatostatin analogue octreotide has an antiemetic effect in patients with gastrointestinal obstruction, but has not been investigated against chemotherapy-induced emesis. The next few years will disclose, whether the efficacy and safety profiles of one or more of these drugs will make it clinically useful in the treatment of chemotherapy-induced nausea and vomiting.

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Citations

Nov 27, 2004·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mark G KrisEnzo Ballatori
Aug 31, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mark G KrisPaul Hesketh
Jul 6, 2002·Critical Reviews in Oncology/hematology·Lisa LicitraFausto Roila
May 9, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P J HeskethK J Horgan
Aug 29, 2000·Inflammatory Bowel Diseases·L B Gerson, G Triadafilopoulos
Mar 15, 2011·Journal of Ethnopharmacology·Qiuhai QianShuanglei Li
Dec 27, 2005·Journal of Gastroenterology·Giuseppe RiezzoFrancesco Russo
Aug 26, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Franziska GeiserAxel Glasmacher

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