Abstract
Platelet activation is a complex mechanism of response to vascular injury and atherothrombotic disease, leading to thrombus formation. A wide variety of surface receptors -integrins, leucine-rich family receptors, G protein coupled receptors, tyrosine kinase receptors- and intraplatelet molecules support and regulate platelet activation. They are potential targets of antiplatelet therapy for the prevention and treatment of arterial thrombosis. Despite the overall clinical benefit of established antiplatelet drugs targeting cyclooxigenase-1 (COX-1), glycoprotein integrin αIIbβ3, and the purinergic P2Y(12) receptor of adenosine diphosphate, a significant proportion of treated patients continue to experience recurrent ischaemic events. This may be in partly attributed to insufficient inhibition of platelet activation. In addition, it should not be underestimated that these drugs are not immune from bleeding complications. The substantial progress in understating the regulation of platelet activation has played a key role in the development of novel antiplatelet agents. Current examples of drug under development and evaluation include: novel P2Y(12) receptor inhibitors (prasugrel, ticagrelor, cangrelor, and elinogrel), thrombin rec...Continue Reading
Citations
May 29, 2014·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Yukinori TamuraJunichiro Yamamoto
Feb 1, 2014·Medicina clínica·Antonio Tello-MontoliuMariano Valdés
Aug 19, 2015·Progress in Cardiovascular Diseases·Francesco FranchiDominick J Angiolillo
Sep 3, 2013·Expert Review of Proteomics·Joanna-Marie Howes
Aug 12, 2015·Purinergic Signalling·Geoffrey Burnstock
Dec 9, 2014·European Journal of Medicinal Chemistry·Noemí VilaCarmen Terán
Dec 3, 2014·European Journal of Pharmacology·Hong-Zhen HaoZhang-Yin Ming
Jul 21, 2012·Platelets·Fabiana RolliniDominick J Angiolillo
Dec 18, 2013·Neurología : publicación oficial de la Sociedad Española de Neurología·M G DelgadoS Calleja
Jun 13, 2013·Bioorganic & Medicinal Chemistry·Andrei A KryskoAlexandre A Varnek
Mar 11, 2015·European Journal of Medicinal Chemistry·Tamara CostasCarmen Terán
Jan 7, 2015·Annual Review of Pharmacology and Toxicology·Jeremiah P Depta, Deepak L Bhatt
Oct 8, 2014·Nature Reviews. Cardiology·Francesco Franchi, Dominick J Angiolillo
Apr 28, 2017·International Journal of Molecular Sciences·Themmila KhamrangJoen-Rong Sheu
Jun 21, 2012·Circulation. Cardiovascular Interventions·José Luis Ferreiro, Dominick J Angiolillo
Sep 21, 2019·Future Medicinal Chemistry·María C Costas-LagoCarmen Terán
Oct 19, 2017·Journal of Thrombosis and Haemostasis : JTH·B R BranchfordJ A Di Paola
Jul 17, 2013·Journal of Thrombosis and Haemostasis : JTH·D CapodannoD J Angiolillo
Aug 12, 2019·Bioorganic & Medicinal Chemistry·Jaiprakash SangshettiDevanand B Shinde
Apr 11, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Eva JoverJosé Rivera
Jun 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bang-Yue LuoJing-Wei Shao
Mar 25, 2021·Clinical Oral Investigations·Thayanne Barbosa Brasil CalciaFrancisco Wilker Mustafa Gomes Muniz