New Perspectives in Clinical Pharmacokinetics-1: the Importance of Updating the Teaching in Pharmacokinetics that both Clearance and Elimination Rate Constant Approaches Are Mathematically Proven Equally Valid

The AAPS Journal
Roger Jelliffe, David Bayard

Abstract

The healing professions have only about four main therapeutic tools at their disposal-surgery, drugs, physical therapy, and psychotherapy. For the general profession of internal medicine, drug therapy is its primary tool. Providing an understanding of the state-of-the-art in therapeutic methods, grounded in solid scientific and mathematical rigor, is therefore of the utmost clinical importance for both physicians and clinical pharmacists. This is particularly true where rapidly evolving scientific changes require an up-to-date education upon which students can rely. Unfortunately, relatively little attention has been paid to training clinical pharmacokineticists and physicians to manage drug therapy optimally for patients under their care in their everyday practice. In this paper, we discuss one of these basic deficiencies from the perspective of the longstanding controversy in pharmacokinetic modeling: whether the volume and clearance approach or the volume and rate constant approach is somehow "better". We examine this controversy using the mathematical principle of invariance, which to our knowledge has not been done before. The conclusion of this analysis is that both approaches are rigorously proven mathematically to be eq...Continue Reading

References

Apr 1, 1973·Journal of Pharmacokinetics and Biopharmaceutics·M RowlandG G Graham
Sep 7, 2004·Journal of Pharmacokinetics and Pharmacodynamics·David S Bayard, Roger W Jelliffe
Sep 17, 2013·British Journal of Clinical Pharmacology·Nikolaos TsamandourasLeon Aarons

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Citations

Sep 5, 2019·The AAPS Journal·Leslie Z BenetJasleen K Sodhi

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