New Perspectives in the Chemistry of Marine Pyridoacridine Alkaloids

Marine Drugs
Alois Plodek, F Bracher

Abstract

Secondary metabolites from marine organisms are a rich source of novel leads for drug development. Among these natural products, polycyclic aromatic alkaloids of the pyridoacridine type have attracted the highest attention as lead compounds for the development of novel anti-cancer and anti-infective drugs. Numerous sophisticated total syntheses of pyridoacridine alkaloids have been worked out, and many of them have also been extended to the synthesis of libraries of analogues of the alkaloids. This review summarizes the progress in the chemistry of pyridoacridine alkaloids that was made in the last one-and-a-half decades.

References

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Citations

Sep 7, 2017·Organic & Biomolecular Chemistry·Kommuru GouthamGalla V Karunakar
May 15, 2018·Marine Drugs·Dianne J Watters
Oct 15, 2021·The Journal of Organic Chemistry·Dongfang Jiang, Shaozhong Wang

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Methods Mentioned

BETA
acylation
acetylation

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