Apr 3, 2014

New perspectives in the renin-angiotensin-aldosterone system (RAAS) III: endogenous inhibition of angiotensin converting enzyme (ACE) provides protection against cardiovascular diseases

PloS One
Miklós FagyasAttila Tóth

Abstract

ACE inhibitor drugs decrease mortality by up to one-fifth in cardiovascular patients. Surprisingly, there are reports dating back to 1979 suggesting the existence of endogenous ACE inhibitors. Here we investigated the clinical significance of this potential endogenous ACE inhibition. ACE concentration and activity was measured in patient's serum samples (n = 151). ACE concentration was found to be in a wide range (47-288 ng/mL). ACE activity decreased with the increasing concentration of the serum albumin (HSA): ACE activity was 56 ± 1 U/L in the presence of 2.4 ± 0.3 mg/mL HSA, compared to 39 ± 1 U/L in the presence of 12 ± 1 mg/mL HSA (values are mean ± SEM). Effects of the differences in ACE concentration were suppressed in human sera: patients with ACE DD genotype exhibited a 64% higher serum ACE concentration (range, 74-288 ng/mL, median, 155.2 ng/mL, n = 52) compared to patients with II genotype (range, 47-194 ng/mL, median, 94.5 ng/mL, n = 28) while the difference in ACE activities was only 32% (range, 27.3-59.8 U/L, median, 43.11 U/L, and range 15.6-55.4 U/L, median, 32.74 U/L, respectively) in the presence of 12 ± 1 mg/mL HSA. No correlations were found between serum ACE concentration (or genotype) and cardiovascular d...Continue Reading

  • References68
  • Citations6

References

Mentioned in this Paper

Neuro-Oncological Ventral Antigen 2
Buffers
Serum Albumin Measurement
Diabetes Mellitus, Non-Insulin-Dependent
Diastolic Blood Pressure Measurement
Kidney Function Tests
Creatinine
Diabetic Nephropathy
Enzymes, antithrombotic
Coronary Artery Disease

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