New perspectives on mTOR inhibitors (rapamycin, rapalogs and TORKinibs) in transplantation

British Journal of Clinical Pharmacology
Matthias WaldnerA W Thomson

Abstract

The macrolide rapamycin and its analogues (rapalogs) constitute the first generation of mammalian target of rapamycin (mTOR) inhibitors. Since the introduction of rapamycin as an immunosuppressant, there has been extensive progress in understanding its complex mechanisms of action. New insights into the function of mTOR in different immune cell types, vascular endothelial cells and neoplastic cells have opened new opportunities and challenges regarding mTOR as a pharmacological target. Currently, the two known mTOR complexes, mTOR complex (mTORC) 1 and mTORC2, are the subject of intense investigation, and the introduction of second-generation dual mTORC kinase inhibitors (TORKinibs) and gene knockout mice is helping to uncover the distinct roles of these complexes in different cell types. While the pharmacological profiling of rapalogs is advanced, much less is known about the properties of TORKinibs. A potential benefit of mTOR inhibition in transplantation is improved protection against transplant-associated viral infections compared with standard calcineurin inhibitor-based immunosuppression. Preclinical and clinical data also underscore the potentially favourable antitumour effects of mTOR inhibitors in regard to transplant...Continue Reading

References

Feb 1, 1977·Canadian Journal of Physiology and Pharmacology·R R MartelS Galet
Mar 1, 1994·European Journal of Immunology·H LuoJ Wu
Dec 14, 1999·British Journal of Clinical Pharmacology·H H NeumayerS Appel-Dingemanse
Mar 27, 2001·Transplantation Proceedings·W JacobsenU Christians
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiroyuki MatsueAkira Takashima
Jan 25, 2003·Transplantation·Paolo MontiLorenzo Piemonti
May 14, 2003·Transplantation Proceedings·S N Sehgal
Apr 11, 2006·Molecular Cell·Dos D SarbassovDavid M Sabatini
Sep 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Sagar B KudchodkarJames C Alwine
Jun 1, 2007·The New England Journal of Medicine·Gary HudesUNKNOWN Global ARCC Trial
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen L ShiaoJordan S Pober
Mar 8, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael A ZimmermanIgal Kam
May 31, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B L KasiskeA Wilkinson
Oct 22, 2008·Gastroenterology·Augusto VillanuevaJosep M Llovet
Jan 16, 2009·Biochemical Society Transactions·Yasemin Sancak, David M Sabatini
Apr 25, 2009·Nature Reviews. Immunology·Angus W ThomsonGiorgio Raimondi
Jun 23, 2009·Nature·Koichi ArakiRafi Ahmed
Feb 26, 2010·Journal of Virology·Nathaniel J Moorman, Thomas Shenk
Feb 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christian TosoNorman M Kneteman
Mar 3, 2010·Immunological Reviews·Michael A SchmidMarkus G Manz
Mar 3, 2010·American Journal of Respiratory and Critical Care Medicine·Dorothy A WhiteRobert J Motzer
Jun 17, 2010·The Journal of Clinical Investigation·Mercedes Rodriguez GarciaJordi C Ochando
Jul 16, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ivana R FerrerMandy L Ford
Aug 14, 2010·Human Immunology·Peter BorosJonathan S Bromberg
Sep 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael HaidingerThomas Weichhart
Sep 14, 2010·American Journal of Respiratory and Critical Care Medicine·Sangeeta BhoradeEdward Garrity
Feb 8, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Oriol BestardJosep M Grinyó
Mar 19, 2011·The Biochemical Journal·Laura R PearceDario R Alessi
Apr 9, 2011·Molecular Cell·Abdelhafid SaciChristopher L Carpenter
Jun 16, 2011·European Journal of Immunology·Sandrine Benhamron, Boaz Tirosh

❮ Previous
Next ❯

Citations

Jun 25, 2016·International Journal of Molecular Sciences·Moto Kajiwara, Satohiro Masuda
Mar 21, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marianna HöselHildegard Büning
Dec 7, 2017·Reviews in the Neurosciences·Sree LalithaBikash Medhi
Oct 19, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sahar SalehiElaine F Reed
May 17, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yassine El HianiXian-Ping Dong
Feb 8, 2018·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Maria J Peláez-JaramilloCarlos O Mendivil
Mar 11, 2018·Clinical Science·Alberto M MartelliJames A McCubrey
May 12, 2019·Cells·Sandra M Ayuk, Heidi Abrahamse
Jul 19, 2019·Materials·Francesca DiomedeJacopo Pizzicannella
Jan 26, 2018·Transplantation·Helio Tedesco Silva
Dec 26, 2019·The Journal of Reproduction and Development·Jianye LiMasashi Takahashi
Mar 7, 2020·Biomolecules & Therapeutics·Annamneedi Venkata PrakashTae Jin Kang
Sep 24, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takuya YashiroChiharu Nishiyama
Mar 11, 2017·Oxidative Medicine and Cellular Longevity·Seraina FaesOlivier Dormond
Jun 20, 2018·Drugs·Steven IvulichGregory Snell
Feb 12, 2020·Molecular Medicine·Deze ZhaoHelei Hou
Jun 18, 2019·Therapeutic Advances in Medical Oncology·Eun Young KimYoon Soo Chang
Dec 22, 2020·Nutrition and Healthy Aging·Sandeep Kumar, Timothy R Peterson
Oct 30, 2020·Frontiers in Aging Neuroscience·Caroline L Benn, Lee A Dawson
Feb 19, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Pedro BrandãoAnthony J Burke
May 8, 2018·Biochemical and Biophysical Research Communications·Wakana SasoKoichi Watashi
Apr 2, 2021·Frontiers in Cell and Developmental Biology·Seraina FaesOlivier Dormond
Apr 4, 2021·Cancers·Alexandre El Hage, Olivier Dormond
Jun 1, 2021·Frontiers in Cell and Developmental Biology·Jia-Yi Li, Wen Li
Jun 9, 2021·Expert Opinion on Therapeutic Patents·Han-Yue QiuMin Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
D Fantus, A W Thomson
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Emily B BordersPatrick J Medina
© 2021 Meta ULC. All rights reserved