New Perspectives on the Use of Phytochemicals as an Emergent Strategy to Control Bacterial Infections Including Biofilms

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Anabela BorgesManuel Simões

Abstract

The majority of current infectious diseases are almost untreatable by conventional antibiotic therapy given the advent of multidrug-resistant bacteria. The degree of severity and the persistence of infections are worsened when microorganisms form biofilms. Therefore, efforts are being applied to develop new drugs not as vulnerable as the current ones to bacterial resistance mechanisms, and also able to target bacteria in biofilms. Natural products, especially those obtained from plants, have proven to be outstanding compounds with unique properties, making them perfect candidates for these much-needed therapeutics. This review presents the current knowledge on the potentialities of plant products as antibiotic adjuvants to restore the therapeutic activity of drugs. Further, the difficulties associated with the use of the existing antibiotics in the treatment of biofilm-related infections are described. To counteract the biofilm resistance problems, innovative strategies are suggested based on literature data. Among the proposed strategies, the use of phytochemicals to inhibit or eradicate biofilms is highlighted. An overview on the use of phytochemicals to interfere with bacterial quorum sensing (QS) signaling pathways and unde...Continue Reading

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Citations

Jul 25, 2019·International Journal of Molecular Sciences·Yvana GlasenappJutta Papenbrock
Nov 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joana F MalheiroManuel Simões
Jul 2, 2020·Natural Product Reports·Roberta J MelanderChristian Melander
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Aug 27, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hassan RasouliReza Khodarahmi
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Jun 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anabela BorgesAlfonso T García-Sosa
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Jun 9, 2018·Journal of Wound Care·Rose Cooper, Klaus Kirketerp-Møller
Jun 24, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Barbara RóżalskaAnna Stochmal
Jul 26, 2019·Marine Drugs·Anabela Borges, Manuel Simões
Aug 30, 2019·Heliyon·Gebreselema GebreyohannesDesta Berhe Sbhatu
Dec 29, 2019·Food Research International·Idalina MachadoManuel Simões
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Methods Mentioned

BETA
environmental stresses

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