PMID: 15224865Jul 1, 2004Paper

New pharmacological strategies to restore hearing and treat tinnitus

Acta Oto-laryngologica
Matthieu J GuittonJean-Luc Puel

Abstract

Recent advances in molecular pharmacology of the cochlea have lead to a much better understanding of the physiology, and especially the pathophysiology, of the sensorineural structures of the organ of Corti. Knowledge of the intimate molecular mechanisms of cellular dysfunction is of considerable use in the development of new therapeutic strategies. Herein, we summarize the mechanisms of sensory hair cell death after various injuries. Based on these molecular mechanisms, we propose novel therapeutic strategies to restore hearing. In addition to permanent hearing loss, exposure to noise or ototoxic drugs also induces tinnitus. We thus review recent findings obtained from a behavioral model of tinnitus in rats. In addition to providing evidence for the site and mechanism of generation of tinnitus induced by salicylate, these results support the idea that targeting cochlear N-methyl-D-aspartate receptors may represent a promising therapeutic strategy for treating tinnitus.

References

Feb 20, 1992·Nature·B MillerD Attwell
Jun 1, 1990·Hearing Research·P H Stypulkowski
Dec 1, 1988·Behavioral Neuroscience·P J JastreboffC T Sasaki
May 12, 1994·Nature·J M KyriakisJ R Woodgett
Oct 3, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·C A BauerM Wyder
Jul 6, 2000·Progress in Neurobiology·Y Cazals

❮ Previous
Next ❯

Citations

Oct 19, 2007·HNO·B MazurekA Szczepek
Feb 19, 2009·Journal of Negative Results in Biomedicine·Birgit MazurekPhilipp P Caffier
Nov 15, 2006·Médecine sciences : M/S·Didier BouccaraOlivier Sterkers
Nov 6, 2012·Expert Opinion on Pharmacotherapy·Berthold Langguth, Ana Belén Elgoyhen
Jun 7, 2011·The American Journal of the Medical Sciences·Mitsuru FukatsuTakashi Joh
Jul 14, 2012·Journal of Psychosomatic Research·Michael LandgrebeBerthold Langguth
Jun 25, 2008·Hearing Research·Jeffrey L HendricksDavid C Martin
Dec 5, 2006·Hearing Research·Colleen G Le PrellJosef M Miller
Jul 7, 2005·Journal of Ethnopharmacology·Paul F SmithCynthia L Darlington
Jul 26, 2018·Annual Review of Pharmacology and Toxicology·Berthold LangguthChristopher R Cederroth
Jan 19, 2005·Current Opinion in Neurology·Paul H Van de HeyningAn Boudewyns
Sep 28, 2021·Drug Discovery Today·John S SchardtPeter M Tessier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Related Papers

Otolaryngologic Clinics of North America
Carol A Bauer
Trends in Neurosciences
Jos J Eggermont, Larry E Roberts
© 2022 Meta ULC. All rights reserved